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Description
human pgp vesicle kit hek293P Glykoproteine MDR1 Assay 100 Reaktionen Das Human Pgp Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient P Glykoprotein (P gp MDR1 ABCB1) berexprimieren. P gp ist einer der klinisch relevantesten Efflux Transporter und ist an zentralen pharmakokinetischen Barrieren wie Darm, Leber, Niere und Blut Hirn Schranke exprimiert. Das Kit ist konform mit den FDA (2017) und EMA (2013) DDI Leitlinien. Hergestellt von Cell4Pharma.
P-Glykoproteine / MDR1 Assay | 100 Reaktionen
Das Human Pgp Vesicle Kit enthält Inside-out-Membranvesikel aus HEK293-Zellen, die transient P-Glykoprotein (P-gp / MDR1 / ABCB1) überexprimieren. P-gp ist einer der klinisch relevantesten Efflux-Transporter und ist an zentralen pharmakokinetischen Barrieren wie Darm, Leber, Niere und Blut-Hirn-Schranke exprimiert. Das Kit ist konform mit den FDA (2017)- und EMA (2013)-DDI-Leitlinien.
Hergestellt von Cell4Pharma. Eine Variante mit dem neuartigen fluoreszenten FluoPgp-Substrat ist ebenfalls erhältlich (C4PVK011).
Exklusiv im DACH-Raum über SeamlessBio erhältlich.
Transporter-Profil
Name: P-gp, P-Glykoprotein, MDR1, Multidrug Resistance Protein 1, Permeabilitätsglykoprotein, ABCB1, ATP-bindende Kassette Unterfamilie B Mitglied 1
Gen: ABCB1
ATP/AMP-Ratio: >5 (garantiert)
Gewebsexpression: Darm, Leber, Niere, Blut-Hirn-Schranke, viele Tumorzellen
Bekannte Substrate: Convallatoxin, Digoxin, N-Methyl-Chinidin (NMQ), Colchicin, Tacrolimus, Chinidin, Etoposid, Doxorubicin
Lagerbestand: Human-Pgp. Ebenfalls verfügbar: Maus- und Ratten-Pgp
Kit Inhalt (100 Reaktionen)
-
- AMP-ATP Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Hinweis: C4PVK011 enthält zusätzlich das neuartige FluoPgp Fluoreszenzsubstrat für fluoreszenzbasierte Detektion ohne Radiolabeling.
Anwendungen
- P-gp-Substratidentifikation und Efflux-Charakterisierung
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Studien zur Multiresistenz (MDR)-Mechanistik
- In-vitro-Bewertung der Blut-Hirn-Schranken-Penetration
- Inhibitionsstudien und IC50-Bestimmung
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
P-Glykoprotein (ABCB1) ist ein primärer Transporter in den FDA (2017)- und EMA (2013)-DDI-Leitlinien. Die Bewertung des P gp-Substrat-und Inhibitorstatus ist für alle neuen Molekülentitäten (NMEs) mit signifikanter oraler oder systemischer Exposition in der klinischen Entwicklung erforderlich.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle) Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel Variante mit FluoPgp-Substrat: C4PVK011
Lagerung: –80 °C
Verwandte Produkte
- Human Pgp Vesicle Kit + FluoPgp Substrat (C4PVK011)
- Fluoreszenz-Detektionsvariante, kein Radiolabeling erforderlich
- Human BCRP Vesicle Kit (C4PVK006) – für parallele BCRP-Efflux-Bewertung
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle
- ciPTEC-OAT1 Assay-Ready Cells – exprimieren funktionelles endogenes P-gp (ABCB1) für zellbasierte Bestätigungsstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
Datasheet
Publikation
Gozalpour E, Wittgen HG, van den Heuvel JJ, et al. Interaction of digitalis-like compounds with p-glycoprotein. Toxicol Sci. 2013,131(2):502-11. doi: 10.1093/toxsci/kfs307
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4.7 ★★★★★
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Product Reviews
★★★★★ 5
Super comfortable!
Size: 9, Color: Navy Blazer/Ivor
Some of the most comfortable shoes that I've ever worn/walked in! Super light on my feet. Nice casual looking and comfortable shoe for a reasonable price. I already brought 3 pair.
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Reviewed in the United States on April 21, 2026
★★★★★ 5
Comfortable Shoes
Size: 12, Color: Navy Blazer/Ivor
This is the second time I purchased this style of shoes. They are extremely comfortable.
They can be worn on casual and business events.
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Reviewed in the United States on May 25, 2026
★★★★★ 5
Great dressy sneaker to wear with business casual or jeans
Size: 11, Color: British Tan/Ivry
I got these for my husband to wear with jeans or business casual dress pants. They look sharp and professional and dress up jeans if you're going out. He says they fit comfortably and he can walk on them all day without his feet hurting. They are beautiful genuine leather so they don't get stinky. I got my husband's normal size and they fit to size.
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Reviewed in the United States on February 11, 2026
★★★★★ 4
Comfortable
Size: 9, Color: Black/Ivory
Most comfortable and roomy shoes I ever wore. Great for insoles. Looks nice too. The base of the shoe is a bit too thick but it’s fine.
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Reviewed in the United States on September 5, 2025
★★★★★ 5
⭐️⭐️⭐️⭐️⭐️ Comfort, Style, and Performance — Perfect for Daily Runs and All-Day Wear!
Size: 11, Color: Black/Dark Smoke Grey
I purchased the Nike Men’s Quest 6 for my son, and he’s been absolutely thrilled with them. From the moment he put them on, he noticed how lightweight and supportive they felt — a great balance between cushioning and responsiveness.
He wears them both for running and casual outings, and they’ve held up beautifully. The breathable mesh upper keeps his feet cool even during longer runs, and the midsole cushioning absorbs impact nicely without feeling too soft or unstable. The grip on the outsole provides solid traction on roads and gym floors, giving confidence with every step.
Design-wise, they look sleek and modern — the classic Nike styling pairs well with both athletic and casual outfits. After several weeks of use, the shoes still look almost new, showing how well they’re built.
Pros:
✅ Lightweight yet supportive — great for running or walking
✅ Comfortable fit right out of the box
✅ Excellent breathability and cushioning
✅ Durable construction that holds up with daily use
✅ Stylish design that transitions easily from workout to casual wear
Cons:
• Runs slightly narrow, so consider sizing up if between sizes
Overall, the Nike Quest 6 offers exceptional comfort and quality for the price. My son says they’re some of the most comfortable shoes he’s ever worn — perfect for both training and everyday wear.
If you’re looking for a reliable running shoe that combines performance, durability, and style, this is an excellent choice.
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Reviewed in the United States on October 5, 2025