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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
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4.1 ★★★★★
Based on 16 reviews
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Product Reviews
★★★★★ 1
One Star
Format: Paperback
Exactly the same as the free PDF I downloaded online for my student, only this costs $26 plus tax.
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Reviewed in the United States on April 3, 2017
★★★★★ 5
The best programming book you will ever read
Format: Paperback
This is without a doubt the best introduction to any programming language you will find. This book takes a hands on approach to learning Python. Concepts are explained clearly and examples and counter-examples are littered throughout each chapters. I like the direct/no waste time with useless preamble approach to explaining key concepts. The explanations are as succinct as it can get. The writer give general advice like not making your solution too generic initially but focus on solving the problem at hand first and then make the code more elaborate. The writer give off a patient tone as he encourages the reader to not be too hard on themselves when they make mistakes but view this as part of the learning process. He gives his own experience and also that of other programmers to encourage the reader to realistically evaluate their circumstances. What I like most about this book is that the exercises are intersperced between the sections within the chapters. That way you get to practice just after learning a new concept. There are final exercises incorporating what was covered in the chapter, the they do not seem to be a summary of all the content. I am reviewing now 23/02/2025. I have read the first 9 chapters and i am currently on chapter 10. When I am done i will update this review.
I use Jupter Notebooks to complete exercises. I head the first cell with the problem number and title and set it as a mark-down cell so it heads that mini section and the code window below contains my solution. That way I have all exercises for a chapter in one file and can easily scroll up to see previous solutions and copy code which the problems requests at times. In the end I envisage I will have 20 files - one per chapter.
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Reviewed in the United States on February 23, 2025
★★★★★ 5
great for beginners
Format: Paperback
simple to understand, good examples
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Reviewed in the United States on May 3, 2026
★★★★★ 5
Great book!
Format: Paperback
Great book! I really like how the instructions are explained in the book and how it encourages you to both use the terminal / python interpreter and make files in vscode. This book can be used for intermediate python programmers and brand new programs. for the intermediate people, its a good refresher of the basics, and by the end you will definitely KNOW, KNOW them. I got this book in prep for new grad job applications, code assessments, game jams, and general practice. So I think you would do good to get this book at any level if you really want to get the basics down and know them!
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Reviewed in the United States on January 2, 2026
★★★★★ 5
One of the best Python books
Format: Paperback
I bought 5 Python books as I needed to learn the language quickly for an upcoming project. Of all the books that I purchased, I found this one to be the best. It starts out with the basics and works its way through more complicated areas. Each chapter builds well upon the other. There is very little redundancy, and I was able to get through the book in about a week. I have a background in software development, so this book was able to show me how Python implements different concepts that I already knew, but I think a beginner would also be comfortable with the material.
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Reviewed in the United States on March 22, 2026