SKU: 9536514756

Methyl-Guard - 180 Capsules | Thorne

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Description

Methyl-Guard - 180 Capsules | ThorneSupports methylation for healthy heart, blood vessels, brain, and bones. The body's methylation process is key to maintaining a healthy level of homocysteine, as well as to multiple other biochemical processes involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. Maintaining a normal homocysteine level in the blood has joined having normal cholesterol and triglyceride levels as

Supports methylation for healthy heart, blood vessels, brain, and bones.

The body's methylation process is key to maintaining a healthy level of homocysteine, as well as to multiple other biochemical processes involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. Maintaining a normal homocysteine level in the blood has joined having normal cholesterol and triglyceride levels as primary objectives for maintaining good cardiovascular health. Because Methyl-Guard promotes healthy methylation, it helps maintain heart, blood vessel, cognitive, nerve, bone, and female reproductive health. Methyl-Guard was the first nutritional supplement on the market to support homocysteine metabolism and healthy methylation using nutrients in their active, tissue-ready forms.


Various conditions and stressors can have an adverse impact on the body’s methylation cycle. For example, nutrient deficiencies and environmental and physical stressors can cause inefficient methylation. In addition, a common human genetic mutation that restricts the activity of a key enzyme in the body involved in methylation affects approximately 60 percent of U.S. adults.  This genetic anomaly poses a significant challenge to efficient methylation – and creates an important need for nutritional support to help rectify it.


Methylation – the addition of a methyl group (CH3 – one carbon attached to three hydrogens) to another molecule – is an essential and vital biochemical process in the body involved in multiple biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for the process of methylation to occur effectively.


Effective methylation must occur to maintain a normal level of homocysteine.A deficiency in the cofactors that metabolize homocysteine is commonly seen in the elderly, thus resulting in increased homocysteine levels in the aging population. An elevated homocysteine level associated with aging, as well as less than optimal levels of folic acid and vitamins B6 and B12, often result in the inefficient methylation of numerous substances, such as DNA and proteins, which in turn decreases the integrity of vascular structures and neurons.Providing the nutritional cofactors for the efficient metabolism of homocysteine also provides support for a healthy brain.


A number of biochemical imbalances that raise the level of homocysteine can be addressed by supplementing with appropriate nutrient cofactors. For example, folic acid (as L-5-methyltetrahydrofolate), vitamin B12 (as methylcobalamin), and betaine (trimethylglycine) help recycle homocysteine to the amino acid methionine, while the recycling of homocysteine into the beneficial amino acids cysteine and taurine is facilitated by pyridoxal 5'-phosphate (the active form of vitamin B6).Studies have shown these nutrients help maintain a normal level of homocysteine in the blood.


Because homocysteine levels can be higher in individuals in which the enzymatic reaction that converts folic acid to the active methyl donor L-5-methyltetrahydrofolate (5-MTHF) does not function properly, Methyl-Guard contains 400 mcg of active 5-MTHF per capsule.

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SKU: 9536514756

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4.6 ★★★★★
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VT
Charlottesville, US
★★★★★ 5
Good for ebike tires
Size: 1 Gallon + Tool, Set name: Small Tire/Bicycle Formula
Got it for my son’s older ebike that my wife rides now. He kept on popping tubes, maybe because of his weight. Anyhow, I fixed it up for my wife and put some FlatOut in it to prevent flats. Seems to work so far. Got the off road FlatOut for my ebike’s fat tires. Easy to add to the tires. The pump clogs up but it’s easy to clean. I will always add this to all tires moving forward!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 4, 2026
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Verified Purchase
Brian ward
Port Orchard, US
★★★★★ 5
Easy to use and works great
Size: 1 Gallon + Tool, Set name: Off-Road Formula
Easy to use
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 22, 2026
K
Verified Purchase
KW
Chelsea, US
★★★★★ 5
Worked on slow leak… one month already!!!
Style: 18oz
Edit: Still holding proper pressure at 2-months !!! Had a slow leak where my tire went from 44psi to ~18psi over 2-3 days… Dashboard light would let me know every few days that I had a tire problem and I would inflate the tire back up to 44psi… Anyway, I used this product and filled air back to 44 psi and it’s held the pressure for a month already !!!! Be sure to deflate tire to ~15 PSI before adding the product… it only took about 30 seconds to empty the container into my tire with the tire pressure low. Very happy with this product !!!
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Reviewed in the United States on April 6, 2026
K
Verified Purchase
Kindle Customer
San Leandro, US
★★★★★ 5
Excellent stuff!
Style: 18oz
Used this on a Z-Trac with a flat and it fixed it and has held up for over 8 months.
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Reviewed in the United States on May 11, 2026
J
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John V. Green
Phoenix, US
★★★★★ 5
Greats stuff
Style: 14oz
Works super, has kept air steaycfor over 6 months, no leaks
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 30, 2026

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