ZBiotics - Pre-Alcohol Probiotic

ZBiotics® Pre-Alcohol Probiotic Drink

ZBiotics® Pre-Alcohol is a science-forward probiotic drink designed to support your body before alcohol consumption by helping break down an unwanted alcohol byproduct called acetaldehyde in the gut. For the full science breakdown, read: How It Works.

Pre-Alcohol is built with Bacillus subtilis ZB183™, a probiotic strain developed using genetic engineering to produce an enzyme similar to the one your liver uses to process acetaldehyde.

The Problem: Acetaldehyde Buildup

When you drink alcohol, your body metabolizes ethanol into acetaldehyde — a highly reactive and unwanted byproduct. Acetaldehyde forms in two places: the liver and the gut.

The liver is well-equipped to process acetaldehyde through a two-step enzyme pathway:

• Alcohol dehydrogenase (ADH) converts ethanol into acetaldehyde (oxidation).
• Acetaldehyde dehydrogenase (ALDH) converts acetaldehyde into acetate (a more stable compound).

However, some alcohol is metabolized in the gut by microbes that can produce ADH, but often do not produce enough ALDH to keep up — which can contribute to acetaldehyde lingering longer than ideal.

The Solution: Engineered Probiotic Support in the Gut

In theory, you could attempt to deliver the ALDH enzyme directly — but enzymes are proteins, and most proteins break down quickly during digestion. ZBiotics took a different approach: use a probiotic that can survive stomach acid and produce the enzyme where it’s needed.

ZBiotics started with Bacillus subtilis, a probiotic species humans have consumed in fermented foods and supplements for a long time. Using genetic engineering, they developed ZB183™ — a strain designed to produce ALDH in the gut to help break down acetaldehyde into acetate.

Want the full walkthrough of the mechanism and research foundation? Read How It Works.

Science Snapshot

• Targets acetaldehyde: Alcohol breaks down into acetaldehyde — an unwanted, highly reactive byproduct that can linger in the gut longer than ideal.
• Gut-focused approach: Pre-Alcohol adds a temporary probiotic that produces an enzyme similar to the one your liver uses to break acetaldehyde down.
• Built on real biotech: Uses a genetically engineered probiotic strain, Bacillus subtilis ZB183™, developed and tested by scientists.

Want the full breakdown? See how it works →

Data, Validation & Quality Standards

ZBiotics reports that ZB183™ has been tested in laboratory settings for safety and functionality, including evaluations designed to confirm ALDH production and acetaldehyde breakdown capacity.

Pre-Alcohol undergoes rigorous quality testing at every stage, and we transparently publish our findings on our Quality page which can be found here: Quality Page.

Nutrition Facts

Not a significant source of saturated fat, trans fat, cholesterol, dietary fiber, total sugars, added sugars, vitamin D, calcium, iron, or potassium.

Ingredients

Water, Natural Flavors, Potassium Sorbate, Sodium Chloride, Bacillus subtilis ZB183™

How to Use

• Drink one bottle before your first alcoholic drink.
• For best results, make it your first drink of the night.
• Hydrate, pace yourself, and drink responsibly.

Alcohol may still affect sleep and overall well-being. A balanced meal, hydration, and proper rest still matter.

FDA Disclaimer:
Statements regarding these products have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.