SKU: 92965594750

Natural Factors PEA400 Palmitoylethanolamide - 90 Capsules

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Description

Natural Factors PEA400 Palmitoylethanolamide - 90 CapsulesPEA400 from Natural Factors is a chronic pain relief formula made from fractionated non GMO safflower seed oil. Palmitoylethanolamide (PEA) is a fatty acid like compound found naturally in certain foods and made within the body. Micronization improves PEAs solubility and absorption to help manage a variety of conditions associated with chronic pain and discomfort. Medicinal Ingredients Each vegetarian capsule contains: Palmitoylethanolamide (safflower

PEA400 from Natural Factors is a chronic pain relief formula made from fractionated non-GMO safflower seed oil. Palmitoylethanolamide (PEA) is a fatty-acid-like compound found naturally in certain foods and made within the body. Micronization improves PEA’s solubility and absorption to help manage a variety of conditions associated with chronic pain and discomfort.

Medicinal Ingredients
Each vegetarian capsule contains:
Palmitoylethanolamide (safflower oil) (seed) 400 mg
PEA (palmitoylethanolamide) is a fatty-acid-like compound naturally found in foods. Natural Factors PEA is naturally produced from fractionated non-GMO safflower oil. It then undergoes a micronization process for improved solubility and absorption. PEA has been shown to be helpful in managing chronic pain and discomfort.

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.

Suggested Use
Studies show that PEA helps relieve chronic pain.
Advanced Info

PEA400 from Natural Factors contains palmitoylethanolamide (PEA) that is naturally sourced from non-GMO safflower oil to help relieve chronic pain. PEA is a fatty-acid-like compound made by the body’s nervous and immune system cells for regulating pain and inflammation. It is also found in certain foods, such as safflower lecithin, soybeans, peanuts, and egg yolks.

PEA has analgesic, neuroprotective, and anti-neuroinflammatory properties. It activates the endocannabinoid system and has been used successfully for conditions associated with chronic pain and discomfort. It has been studied for nerve compression syndromes, including sciatica and carpal tunnel syndrome, and for pain caused by pinched nerves and temporomandibular joint (TMJ) disorders.

PEA400 is made from fractionated non-GMO safflower oil. It then undergoes a micronization process to improve its solubility and absorption by the body. Each vegetarian capsule contains 400 mg of PEA to be taken in a daily dose of three capsules, which is within the range of doses supported by clinical studies. PEA400 is suitable for vegetarians and vegans, and is well tolerated with little to no reported side effects. It is a great choice for adults who suffer from chronic pain conditions but have had limited success with conventional therapies.

 

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SKU: 92965594750

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Marina Gulley
Boise, US
★★★★★ 4
Good product , but
Size: 1.3 Fl Oz (Pack of 1), Size: 1.3 Fl Oz (Pack of 1)
It seems to be a good product and it’s not too heavy , but still caused few breakouts here and there . Also, Avenue always has protective foil on their cream , this one didn’t have (I replaced it but new one also didn’t have it). Also, it goes away really fast because it’s only 1.3 ounces.
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Reviewed in the United States on April 12, 2026
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Avid Reader
Natrona Heights, US
★★★★★ 5
Hydrating
Size: 1.3 Fl Oz (Pack of 1)
Dermatologist recommended. Works very well
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Reviewed in the United States on May 16, 2026
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Violet
Omaha, US
★★★★★ 5
Gold Star
Size: 1.3 Fl Oz (Pack of 1)
This cream is truly gentle and healing for a compromised skin barrier. I prefer this cream in the winter, when the weather is dry, and after procedures like microneedling or laser. It has never irritated my skin, and does soothe and heal. The La Roche Posay cicalfate cream is also excellent, I think it is slightly less rich, so I prefer that in humidity or the summer.
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Reviewed in the United States on March 2, 2026
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NikkiB
San Leandro, US
★★★★★ 5
Overpriced but it works.
Size: 1.3 Fl Oz (Pack of 1)
I hate that I love this product. It's stupid expensive. But it's great for broken/damaged/recovering skin. I've used it post microneedling and it is the only thing that soothes, hydrates, and doesn't sting raw, red skin. Great for rashes/hives and allergic reactions too. Luckily a thin layer is often enough to do the trick. so it lasts a long time I wouldn't use for everyday moisture, but when your skin is angry, this stuff works. (Overpriced? Yes. Witchcraft? Maybe. Does it work? Yep.)
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Reviewed in the United States on December 10, 2025
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English farmhouse
Lake Worth, US
★★★★★ 5
Works wonder
Size: 1.3 Fl Oz (Pack of 1)
Amazing product. The scars from my daughter acne are mostly gone after 1 month. We will purchase again
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Reviewed in the United States on February 27, 2026

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