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Description
Synaptotagmin-1 (SYT1) Recombinant Rabbit mAb (S-2226-76)Product Specification Host Rabbit Antigen Synaptotagmin 1 (SYT1) Synonyms Synaptotagmin I (SytI); p65; SVP65; SYT Immunogen Synthetic Peptide Location Cytoplasm, Synapse Accession P21579 Clone Number S 2226 76 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample Mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Synaptotagmin-1 (SYT1) |
| Synonyms | Synaptotagmin I (SytI); p65; SVP65; SYT |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Synapse |
| Accession | P21579 |
| Clone Number | S-2226-76 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
Synaptotagmin-1 (SYT1) is a crucial calcium sensor protein predominantly located in the presynaptic terminals of neurons. It plays a vital role in the process of neurotransmitter release by facilitating the rapid and precise fusion of synaptic vesicles with the presynaptic membrane. When an action potential reaches the presynaptic terminal, the influx of calcium ions triggers conformational changes in SYT1, which then interacts with key components of the fusion machinery, such as SNARE proteins, to initiate the release of neurotransmitters into the synaptic cleft. This protein is essential for maintaining proper synaptic function and ensuring efficient communication between neurons in the nervous system.
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