SKU: 12900851026

CLEC12A/MICL/CLL-1 His Tag Protein, Mouse

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Description

CLEC12A/MICL/CLL-1 His Tag Protein, MouseProduct Specification Species Mouse Synonyms CLEC12A, MICL, CLL 1, CLL1, DCAL2, DCAL 2, CD371 Accession Q504P2 1 Amino Acid Sequence Tyr65 Arg267, with N terminal 8*His HHHHHHHHGGGSYTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR Expression System HEK293 Molecular Weight 28 40kDa Purity >95% by SDS

Product Specification


Species Mouse
Synonyms CLEC12A, MICL, CLL-1, CLL1, DCAL2, DCAL-2, CD371
Accession Q504P2-1
Amino Acid Sequence Tyr65-Arg267, with N-terminal 8*His HHHHHHHHGGGSYTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR
Expression System HEK293
Molecular Weight 28-40kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Lahoud M H. et al. (2009) The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J Immunol. 182(12): 7587-7594.

2、Pyz E. et al. (2008) Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. Eur J Immunol. 38(4): 1157-1163.

3、Marshall A S. et al. (2006) Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. Eur J Immunol. 36(8): 2159-2169.

Background

Clec12a (also called myeloid inhibitory C-type lectin-like receptor, MICL) was originally described as an ITIM-containing inhibitory CLR expressed by human granulocytes and monocytes. It was suggested that Clec12a recognizes some endogenous ligands as soluble Clec12a could bind to single-cell suspensions isolated from various murine tissues. CLEC12A is a myeloid lineage antigen that is highly expressed by AML cells and LSCs, but not expressed by normal hematopoietic stem cells (HSCs), thus minimizing off-target toxicity.
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SKU: 12900851026

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Boise, US
★★★★★ 5
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Format: Hardcover
Our grandkids love us to read to them. We have way over 30 of these books. This one is a favorite.
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Reviewed in the United States on December 20, 2024
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Lacey
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★★★★★ 5
Caught my kids with it
Format: Hardcover
Heard my kids talking upstairs after bedtime one night so I went up to tell them to be quiet and go to bed. Lo and behold my 6 year old is sitting in bed with my 3 year old and reading her a bedtime story out of this book. At that point I couldn’t interrupt so I just let them finish while having a proud parent moment.
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Reviewed in the United States on June 21, 2022
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W. Gover
Waukegan, US
★★★★★ 5
Enchanting Short Stories That Delight Young Readers
Format: Hardcover
Disney Princess: 5-Minute Princess Stories is a delightful collection that brings magic and imagination to storytime in just a few minutes per tale. Each story is engaging, easy to follow, and filled with beloved princess characters that capture children’s attention and spark creativity. The colorful illustrations enhance the reading experience, making it fun for both kids and adults to enjoy together. Perfect for bedtime, travel, or quick reading breaks, this book offers charming, memorable moments that young readers will treasure again and again.
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Reviewed in the United States on March 4, 2026
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Jordan
Charlottesville, US
★★★★★ 5
Great for story time!
Format: Hardcover
We love Disneys 5 minute story books and this Disney princess one is perfect. The story do take about 5 minutes to read and they are not just a recap of the movie but rather another story with the Disney characters. My daughter loves the pictures
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Reviewed in the United States on April 16, 2026
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Doc
Grantham, US
★★★★★ 5
VERY CAPTIVATING
Format: Hardcover
Bought this for our 3 year old granddaughter ... and ... are great for bedtime stories. Even re-reading them she found them fun, interesting, and captivating. The stories are indeed 5 minutes in duration and it flows perfectly to increase the listeners attention. These stories are perfect for young girls as the stories are about famous princesses.
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Reviewed in the United States on December 7, 2025

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