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Description
FITC Labeled-GUCY2C His Tag Protein, HumanProduct Specification Species Human Synonyms GC C,STAR,DIAR6,GUC2C,MECIL,MUCIL Accession P25092 Amino Acid Sequence Ser24 Gln430 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 90 115kDa (Reducing) Conjugation FITC Tag His Tag Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months from date of receipt, lyophilized powder stored at 20 to 80. 3 months, 20 to 80 under sterile conditions after
Product Specification
| Species | Human |
| Synonyms | GC-C,STAR,DIAR6,GUC2C,MECIL,MUCIL |
| Accession | P25092 |
| Amino Acid Sequence | Ser24-Gln430 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-115kDa (Reducing) |
| Conjugation | FITC |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1、Blomain E S. et al. (2016) Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer. Molecular Pharmacology. 90(3): 199-204. |
Background
Guanylyl cyclase C (GUCY2C) is a membrane-bound receptor that produces the second messenger cGMP following activation by its hormone ligands guanylin or uroguanylin, regulating intestinal homeostasis, tumorigenesis, and obesity. In turn, cGMP signaling regulates homeostatic processes in intestine that are canonically disrupted in cancer, including maintenance of DNA integrity and genomic stability. GUCY2C is expressed mostly on the apical surface of intestinal cells but also in the kidney, airway epithelium, perinatal liver, stomach, brain, adrenal glands, and reproductive tissues. Analogous to other rGCs, the primary sequence of GUCY2C reveals a multidomain architecture. Residues 1-23 comprise a putative signal peptide that directs the receptor to the cell surface. This is followed by the ECD (residues 24-430). The intracellular region has a short juxta-membrane domain (residues 455-489) which is followed by a kinase-homology domain (KHD) (residues 490-735), the linker region (residues 736-810), the guanylyl cyclase domain (GCD) (residues 811-1,010), and a C-terminal domain (CTD) (residues 1,011-1,073). Guanylyl cyclase C receptor (GUCY2C) and its hormones, uroguanylin and guanylin, have emerged as a key signaling axis opposing mutations driving intestinal tumorigenesis.
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