SKU: 14107086715

Mouse Anti-Human CD268 (BAFF Receptor) Antibody (S-4520)

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Description

Mouse Anti-Human CD268 (BAFF Receptor) Antibody (S-4520)Product Specification Host Mouse Antigen CD268 (BAFF Receptor) Synonyms Tumor necrosis factor receptor superfamily member 13C; B cell activating factor receptor; BAFF receptor (BAFF R); BLyS receptor 3; BAFFR; BR3; TNFRSF13C Location Membrane Accession Q96RJ3 Clone Number S 4520 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical

Product Specification


Host Mouse
Antigen CD268 (BAFF Receptor)
Synonyms Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor (BAFF-R); BLyS receptor 3; BAFFR; BR3; TNFRSF13C
Location Membrane
Accession Q96RJ3
Clone Number S-4520
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

CD268, also known as the B-cell Activating Factor Receptor (BAFF-R or BR3), is a type III transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily that plays a pivotal role in B lymphocyte biology by serving as the primary high-affinity receptor for BAFF (BLyS). Predominantly expressed on the surface of mature and transitional B cells, CD268 is essential for B cell survival, maturation from the transitional to the follicular stage, and the maintenance of peripheral B cell homeostasis through the activation of key signaling pathways such as NF-κB (both canonical and non-canonical), PI3K/Akt, and MAPK. Upon binding to its ligand BAFF, CD268 prevents apoptosis by upregulating anti-apoptotic proteins like Bcl-2 and Mcl-1, thereby ensuring the longevity of the B cell pool; conversely, defects or deficiencies in CD268 signaling lead to a severe reduction in mature B cell numbers and impaired humoral immunity. Due to its critical function in B cell survival, CD268 is a significant therapeutic target in autoimmune diseases characterized by B cell hyperactivity, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, as well as in B cell malignancies, where blocking this receptor can effectively induce the depletion of pathogenic or malignant B cells.

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SKU: 14107086715

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4.9 ★★★★★
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New Z Land Farms
Pawtucket, US
★★★★★ 4
Insightful and Compassionate.
Format: Hardcover
I really love Nedra Glover Tawwab's work. I started with "Set Boundaries, Find Peace" and that opened the gateway to a broader and more helpful healing journey for me. This book, "Drama Fee" was just an evolutionary step in her series and a more in depth dealing with family relationships. The different perspectives for each chapter on how the concept can be applied was/is helpful as it often feels like books of this nature are only telling the black or white way to focus on a relationship. I felt seen and heard that though my familial relationships are unique there are commonalities and in turn ways to approach healing, reconciliation (with oneself and with family), understanding and compassion, to a achieve drama free relationships. As humans we are bread for connection and I appreciate Nedra Glover Tawwab's help in navigating them.
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Reviewed in the United States on June 9, 2025
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Diane Burroughs
Lake Worth, US
★★★★★ 5
Being Our True Selves In Relationships That Matter
Format: Kindle
Nedra Glover Tawwab is a New York Times bestselling author, a licensed therapist, and a sought-after relationship expert. This book is a therapeutic and educational tool that addresses how to consciously change behaviors you’d rather not have in relationships, specifically, around your family. For those of us who have delved into the self-help book world, this is an in-depth, thorough refresher, focusing on family dynamics. Nedra’s core belief is that relationships contribute to mental health. They can cause you pain or they heal you. She focuses on taking your relationships seriously and teaches the art of having tough but intentional conversations to create positive change. OR you’ll learn how to sever ties when the relationship is unmanageable. None is more influential than the formative years we’ve had with our family of origin. A lot of people lament that not everything is about the family, but yup, so often it’s true. In childhood, most likely we weren’t allowed to be ourselves, so our true selves started to develop when becoming an adult. Like a butterfly using its colossal strength to break out of its chrysalis, we too must use our emotional colossal strength to break out of our childhood mold in order to fly. We are able to have relationships with family on our terms.
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Reviewed in the United States on July 3, 2023
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Athena
Boise, US
★★★★★ 5
Read. This. Book.
Format: Kindle
Read this book if you have a dysfunctional family or relationship with family members (including in-laws and extended family). Read this book if you think you don’t. Nedra outlines several different types of familial relationships and how challenging it can be to work through dysfunction or things we have considered normal that are not. Nedra also provides wisdom and tools on how to overcome the many challenges that occur in relationships with family members with gentleness, understanding and realistic observations and advice. Please keep in mind that there will likely be much to unpack from both your childhood and adulthood. It can be an incredibly emotional process in which you might need to take breaks and pauses. However, it is a worthwhile endeavor that will allow you a new, healthier perspective on your relationships with others, and it will cause you to re-evaluate yourself and how you interact with others. This is necessary wisdom for cultivating peace and harmony in your life. I wish fellow readers an eye-opening and heartfelt journey. Be kind and gracious to yourself during this experience and best wishes in creating and living your most authentic life.
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Reviewed in the United States on March 8, 2023
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Cara
Whiting, US
★★★★★ 5
Great!
Format: Hardcover
Love Nedra - I recommend this book to all my clients!
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Reviewed in the United States on January 16, 2026
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endrina diaz
Port Orchard, US
★★★★★ 5
Excelente libro
Format: Paperback
Excelente libro lo recomiendo 👍 llego super bien y en buen estado
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Reviewed in the United States on March 11, 2026

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