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Description
PrPC Recombinant Rabbit mAb (S-2053-29)Product Specification Host Rabbit Antigen PrPC Synonyms Major prion protein; PrP; ASCR; PrP27 30; PrP33 35C; CD230; ALTPRP; PRIP; PRNP Immunogen Synthetic Peptide Location Cell membrane Accession P04156 Clone Number S 2053 29 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample SK MEL 28 Predicted Reactivity Gor, Or Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | PrPC |
| Synonyms | Major prion protein; PrP; ASCR; PrP27-30; PrP33-35C; CD230; ALTPRP; PRIP; PRNP |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P04156 |
| Clone Number | S-2053-29 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | SK-MEL-28 |
| Predicted Reactivity | Gor, Or |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
The cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein encoded by the PRNP gene and predominantly expressed in neurons, although it is also found in other tissues such as lymphoid organs and the heart. PrPC has a flexible N-terminal tail and a structured C-terminal core, allowing it to interact with a wide range of partners. Its proposed physiological functions include ion balance homeostasis, neuritogenesis, neuronal protection against oxidative stress, and modulation of cell signaling pathways. However, only its role in peripheral nerve myelination homeostasis has been definitively confirmed. Misfolding of PrPC into the pathogenic PrPSc isoform leads to prion diseases, which are characterized by neurodegeneration.
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