SKU: 14568625816

APC Mouse Anti-Rat CD44H Antibody (S-R623)

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Description

APC Mouse Anti-Rat CD44H Antibody (S-R623)Product Specification Host Mouse Antigen Rat CD44H Synonyms CD44s; CD44A; METAA; RHAMM; CD44; Pgp 1; H CAM; CD44st; CD44std Location Cell membrane Accession P26051 Clone Number S R623 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Rt Positive Sample Wistar Rat splenocytes Purification Protein A Concentration 0. 05mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12

Product Specification


Host Mouse
Antigen Rat CD44H
Synonyms CD44s; CD44A; METAA; RHAMM; CD44; Pgp-1; H-CAM; CD44st; CD44std
Location Cell membrane
Accession P26051
Clone Number S-R623
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Rt
Positive Sample Wistar Rat splenocytes
Purification Protein A
Concentration 0.05mg/ml
Conjugation APC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300
Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Rt

Background

CD44H protein, also known as the standard form of CD44, is a widely expressed cell surface adhesion molecule that plays crucial roles in various cellular processes. It is a transmembrane, highly glycosylated protein primarily involved in cell-cell and cell-matrix interactions, particularly through its binding to hyaluronic acid (HA), a major component of the extracellular matrix. CD44H is expressed on most immune cells, including lymphocytes, monocytes, and granulocytes, and is also found on epithelial, endothelial, and mesenchymal cells. The protein's function includes facilitating cell motility, proliferation, and immune cell activation. In the context of cancer, CD44H is often overexpressed and is considered a marker for cancer stem cells, contributing to tumor development, metastasis, and chemoresistance. Its interaction with HA and other extracellular matrix components is essential for these processes. Additionally, CD44H is involved in the regulation of immune responses, including lymphocyte activation and homing. The protein's cytoplasmic domain interacts with the cytoskeleton and signaling molecules, further modulating cellular behavior.

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SKU: 14568625816

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4.0 ★★★★★
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DoubtfulReader
Louisville, US
★★★★★ 3
Notes on Legal Style by a Law Professor and Experienced Lawyer.
Format: Kindle
BOOK REVIEW: MEYER, Philip N., Storytelling for Lawyers ISBN: 978-0-19-5396638 Read June, 13th-27th, 2017. This book discusses storytelling tools by presenting a series of examples of good storytelling, both in legal settings and in literary works and movies. If theoretical explanations are sometimes a bit dry, the frequent quoting of practical examples conveys fluidity and speed to the book. After an introduction presenting lawyers as storytellers, it deals with the roles played in storytelling by Plots (chapters 2 and 3); Character (4 and 5); Voice, Perspective, Details and Images, and Rhytm and Speed (which relate to Scene and Summary) (chapter 6); Place or Story Environment (chapter 7) and Narrative Time. Focusing maybe too narrowly on legal storytelling before American juries, plot is almost equated with melodrama. Films like Jaws and High Noon are extensively discussed, as Gerry Spence’s Closing Argument on Behalf of Karen Silkwood. The chapters on character offer interesting insights on character classification (“round” characters, with psychological depth, prone to suffer transformation as the story evolves, vs. “flat” ones), while discussing the tools for telling how a character is, as opposed to simply showing the psychological nature of each character’s character through dialogue or the actions the character performs. Examples include Tobias Wolff’s This Boy’s Life and Jeremiah Donovan’s Closing Arguments on Behalf of Louis Failla, in a 13-week trial the Author could scrupulously attend in person. Discussions on Voice, Perspective, Details and Images, Scene and Summary, criticize the basic assumptions of the neutrality of lawyers’ voices, exemplifies how to manage details to suggest ideas and emotions, draw on the distinction between showing and telling, and offers interesting insights into the narrative theory’s concept of stretch (the slowing of the narrative rhythm in relation to the narrated story’s). Environment depiction storytelling tools deals with Joan Didion’s The White Album and the Judicial Opinion in a Rape Case, quoting also from W. G. Sebald’s The Emigrants and the Petition Briefs in Reck v. Ragen and Miranda v. Arizona. Further examples are Kathryn Harrison’s While They Slept and the Petitioner’s Brief in Eddings v. Oklahoma. Finally, the chapter on Narrative Time draws on Kurt Vonnegut’s Slaughterhouse Five and explores time, rhythm or speed, discussing more deeply stretch and the relation of time of the narrative itself with the time of the facts dealt with in the narrative. Chronology is discussed and criticized; Analepsis or Flashback is didactically explained and exemplified, both in general storytelling theory and in its legal use; the same holds for Prolepsis (Flash-forward) and Ellipsis (the intentional omission of a part of the narrative, often with the purpose of emphasizing the omitted event. Pacing and Rhythm are discussed in more lenght, with the caveat - repeated somewhat throughout the book - that legal stories are often left unfinished by the lawyer, in order to allow the jurors or judges fill the end with their decision. The Author remarks his purpose was to suggest possible tools and ways of dealing with problems which arise in legal storytelling, and he delivers what he promises.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 27, 2017
M
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Matt M.
New York, US
★★★★★ 5
Great book and great professor
Format: Paperback
Professor Meyer is a great writer. I had took his death penalty case at Vermont Law School. He writes for numerous magazines including the ABA. I would highly recommend this book and all of his writings.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 19, 2021
J
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J. Christian
Fort Morgan, US
★★★★★ 4
Interesting book
Format: Paperback
I am not a lawyer, nor a writer, but rather a reader. I found the correlation of legal storytelling with sceenplay, literary narrative quite interesting. Legal trials are theater.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 20, 2014
C
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Classics professor
Charlottesville, US
★★★★★ 5
Highly recommended -- not just for lawyers!
Format: Paperback
I'm not a lawyer but a Classics professor looking for modern parallels to (and contrasts with) Cicero's persuasive strategies in Roman courts. This book was just what I was looking for: lucid, informative, smart, and as a bonus, well versed in narrative theory, which Meyer handles as an experienced teacher -- avoiding jargon and needless complication, illustrating the key ideas with well-known cinematic examples.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 20, 2017
D
Verified Purchase
Danley Wolfe
Whiting, US
★★★★★ 5
Super overview and commentary on the historiy and many iterations/amendments
Format: Hardcover
I purchased and carefully read Jeff Kosseff's "The Twenty-Six Words That Created the Internet." It is an illuminating and thorough account of all facets of the legislation including history, enactment, modifications and amendments etc. A complex subject to understand, Mr. Kosseff did an outstanding job of presenting the complicated history and details and understanding of why this is incredibly important leading up to the form that is now in use. Some reviewers complain about too much detail, but I disagree, it is very important to understand the detail. A difficult topic and a great job of presentation. I would like to have a time line e.g., something like a "herring bone" chart notating all of the critical stages of development up to the present ... from initial concepts to Section 230 rollout and the important changes / amendments in both substance and use of 230. I am now reading Koseff's latest book on a similar but different topic, "The United States of Anonymous" which deals with how the first amendment shaped the development of our online speech.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 16, 2023

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