Pay in installments of $10.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 10 - Sep 15
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Rat Anti-Mouse Siglec-H Antibody (S-3779)Product Specification Host Rat Antigen Siglec H Synonyms Siglec H; Siglech Location Membrane Accession Q3Y597 Clone Number S 3779 Antibody Type Rat mAb Isotype IgG2b Application FCM Reactivity Ms Positive Sample Fresh C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied
Product Specification
| Host | Rat |
| Antigen | Siglec-H |
| Synonyms | Siglec-H; Siglech |
| Location | Membrane |
| Accession | Q3Y597 |
| Clone Number | S-3779 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | Fresh C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
Siglec-H is a sialic acid-binding Ig-like lectin expressed almost exclusively on murine plasmacytoid dendritic cells (pDCs) and microglia, where it partners with the ITAM-bearing adaptor DAP12 to deliver inhibitory signals that restrain type I interferon (IFN-α) secretion, limits TLR7/9-mediated viral responses, and thereby prevents overt systemic autoimmunity while still permitting antigen uptake and presentation; genetic deletion or antibody-mediated ligation of Siglec-H heightens IFN-α output, skews T-cell polarization toward IL-21⁺ CD4 subsets, and can either exacerbate or attenuate inflammatory diseases depending on context, making it a key rheostat of innate–adaptive immune crosstalk.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy