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Description
BLAME/SLAMF8 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms BLAME,SLAMF8,CD353 Accession Q9P0V8 1 Amino Acid Sequence Ala23 Asp233, with C terminal Fc Expression System HEK293 Molecular Weight 55 60kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | BLAME,SLAMF8,CD353 |
| Accession | Q9P0V8-1 |
| Amino Acid Sequence | Ala23-Asp233, with C-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 55-60kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Sci Rep . 2020 Feb 13;10(1):2505. |
Background
B-lymphocyte activator macrophage expressed (BLAME), also known as SLAMF8, is a type I transmembrane protein that belongs to the CD2 subset of immunoglobulin superfamily cell receptors. BLAME is a cell surface receptor that is expressed upon activation of macrophages (MΦs) by IFN-γ or bacteria, is a negative regulator of ROS in response to Gram+ and Gram- bacteria. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. BLAME is highly expressed in T cells of childhood cancer and Epstein-Barr virus positive gastric cancer, and is a potential immunotherapeutic target for a variety of diseases.
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