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Description
FITC Rat Anti-Mouse CD326 Antibody (S-R627)Product Specification Host Rat Antigen CD326 Synonyms Epithelial cell adhesion molecule; Ep CAM; Epithelial glycoprotein 314; Protein 289A; Tumor associated calcium signal transducer 1; Tacstd1; Epcam Location Cell membrane Accession Q99JW5 Clone Number S R627 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse thymocytes Purification Protein G Concentration 0. 2 mg ml Conjugation FITC Physical Appearance
Product Specification
| Host | Rat |
| Antigen | CD326 |
| Synonyms | Epithelial cell adhesion molecule; Ep-CAM; Epithelial glycoprotein 314; Protein 289A; Tumor-associated calcium signal transducer 1; Tacstd1; Epcam |
| Location | Cell membrane |
| Accession | Q99JW5 |
| Clone Number | S-R627 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD326, also known as EpCAM (epithelial cell adhesion molecule) or TACSTD1 (tumor-associated calcium signal transducer 1), is a 40 kDa type I transmembrane glycoprotein that serves as a calcium-independent homophilic cell adhesion molecule in the basolateral membranes of most epithelial cells. It plays a crucial role in cell adhesion, proliferation, and differentiation, and is highly expressed in various normal epithelial tissues, such as the gastrointestinal tract and liver. However, its expression is significantly upregulated in many epithelial cancers, including colorectal, breast, and prostate cancers, making it a valuable tumor marker. In cancer biology, CD326 is involved in tumor progression, metastasis, and the maintenance of cancer stem cells. It also has potential therapeutic applications, such as targeted drug delivery and immunotherapy, due to its specific expression on cancer cells.
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