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Description
Alexa Fluor® 647 Mouse Anti-Human CD141 Antibody (S-2870)Product Specification Host Mouse Antigen CD141 Synonyms Thrombomodulin; TM; Fetomodulin; CD141; THRM; THBD Location Membrane Accession P07204 Clone Number S 2870 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from
Product Specification
| Host | Mouse |
| Antigen | CD141 |
| Synonyms | Thrombomodulin; TM; Fetomodulin; CD141; THRM; THBD |
| Location | Membrane |
| Accession | P07204 |
| Clone Number | S-2870 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD141, also known as thrombomodulin, is a 75 kDa single-chain type I membrane glycoprotein that serves as a crucial cofactor in the protein C anticoagulant system. It is expressed on various cell types, including endothelial cells, monocytes, dendritic cells, and keratinocytes. When thrombin binds to CD141, it activates protein C, which degrades clotting factors Va and VIIIa, thereby reducing thrombin generation and preventing excessive blood coagulation. Additionally, CD141 is involved in embryonic development and atherosclerotic plaque formation. In the immune system, CD141+ dendritic cells have been shown to produce significant amounts of IFN-α in response to certain stimuli, indicating their important role in immune responses.
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