SKU: 2027537705

Phospho-TAZ (ser89)/Phospho-YAP (Ser127) Recombinant Rabbit mAb (S-1364-129)

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Description

Phospho-TAZ (ser89)/Phospho-YAP (Ser127) Recombinant Rabbit mAb (S-1364-129)Product Specification Host Rabbit Antigen Phospho TAZ (ser89) Phospho YAP (Ser127) Synonyms WW domain containing transcription regulator protein 1; Transcriptional coactivator with PDZ binding motifImported; TAZ s; WWTR1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession Q9GZV5P46937 Clone Number S 1364 129 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Rt Positive Sample PANC 1, HeLa (treated

Product Specification


Host Rabbit
Antigen Phospho-TAZ (ser89)/Phospho-YAP (Ser127)
Synonyms WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motifImported; TAZ s; WWTR1
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus, Cell membrane
Accession Q9GZV5、P46937
Clone Number S-1364-129
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Rt
Positive Sample PANC-1, HeLa (treated with 100 ng/ml Calyculin A for 30 minutes), C6 (treated with 100 ng/ml Calyculin A for 30 minutes)
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Rt

Background

Phospho-TAZ (Ser89) and Phospho-YAP (Ser127) are the inactivated forms of the transcriptional coactivators TAZ (also known as WWTR1) and YAP (Yes-associated protein), respectively, following phosphorylation at serine residue 89 and serine residue 127, representing the activation state of the Hippo signaling pathway. These two phosphorylation sites are located within the 14-3-3 protein binding regions of TAZ and YAP, respectively. When the upstream kinase cascade (such as MST1/2 and LATS1/2) is activated, LATS1/2 directly phosphorylates YAP at Ser127 and TAZ at Ser89. The phosphorylated YAP/TAZ then bind to 14-3-3 proteins in the cytoplasm, leading to cytoplasmic sequestration and ubiquitin-mediated degradation, thereby preventing their nuclear translocation and transcriptional regulatory functions. The Hippo signaling pathway regulates the phosphorylation status of TAZ and YAP, participating in the control of organ size, tissue homeostasis, cell proliferation, and apoptosis. In various tumors, reduced phosphorylation levels of TAZ/YAP (i.e., enhanced activation) are commonly observed. These phosphorylation sites are typically detected using specific antibodies via methods such as immunoblotting or immunohistochemistry, serving as key molecular markers for assessing Hippo signaling pathway activity and the nuclear translocation status of TAZ/YAP.

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SKU: 2027537705

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4.5 ★★★★★
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K
Verified Purchase
Kimberly B
Houston, US
★★★★★ 4
not bad
Format: Kindle
I loved the plot of this book. The characters just didn’t have a lot of depth. The connections and “love” just weren’t communicated very well in the writing. The author didn’t write the sweet psycho trope very well at all either. Lachlan was just a mess of a character.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 17, 2023
C
Verified Purchase
Carmen Alicea
San Leandro, US
★★★★★ 5
A Beta Worth Rooting For
Format: Kindle
In Spare, Violet Fox flips the omegaverse on its head, giving us a Beta heroine determined to make her mark. Joining the Beta Trials to support her sick father, she's thrown into a pack that doesn't want her, especially the possessive Alphas. But here's the twist: their sweet Omega turns out to be her scent match. Cue the angst, forbidden tension, and a slow-burn romance that will make your heart ache in the best way. Violet Fox delivers an emotional, refreshing take on the genre, proving Betas aren't "spares." They're stars.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 10, 2025
C
Verified Purchase
C. Hunter
Carnegie, US
★★★★★ 5
Beta, Alpha, Omega oh my!
Format: Kindle
Omegas are precious and given to Alphas & their packs... but the Betas want in too. To this end, the Beta government is rolling out its trial of assigning a Beta to each Alpha-Omega pack. But forcing a Beta into a pack where they are not wanted will not end well... Of course, no one expected the Omega to fall for the assigned Beta. Great read and cliffhanger
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2025
B
Verified Purchase
B. Stubby
Birmingham, US
★★★★★ 3
A familiar story, just with…..less.
Format: Kindle
So, as other reviewers make clear, this is very similar to Pack Darling and The Beta. It’s much closer aligned with The Beta, in plot and maybe more like Pack Darling with characters. That being said, I don’t hate this…..but it wasn’t great either. It’s both books mentioned but just….less. Less angst, less emotion, less feeling. The plot feels very half fleshed out, and the “bad guy” feels underwhelming. I didn’t really feel any real emotions from and of the male leads, except maybe Oliver. The others fell sorta flat for me. And Mika makes herself out to be this big bad ass straight outta training and then we never see it from here again with the one fitting room incident as the exception. SPOILER: The whole, “Oh, I’m actually probably an Omega, but I don’t wanna be but I do actually wanna be but no one can ever know my secret that I do nothing to hide “ thing fell so flat. She never commutes to believing she was secretly an omega, but also mentions her “secret” a lot. It just felt so manufactured. I’m intrigued enough to read part 2 and see how the author closes everything out, but this is not one I’ll recommend or ever come back to.
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Reviewed in the United States on February 13, 2024
R
Verified Purchase
Ruth Ann Burt
West Palm Beach, US
★★★★★ 5
Great book
Format: Kindle
I absolutely feel in love with all 4 characters!!! The bedroom scenes were 🌋🌡🔥🔥🔥. I couldn't put this book down!!! I'm hooked for the whole series Book 2 here I come!!!!! Its a fun easy book and story to read!!
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Reviewed in the United States on October 4, 2024

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