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Description
CK1α Recombinant Rabbit mAb (SDT-2884-60)Product Specification Host Rabbit Antigen CK1 Synonyms Casein kinase I isoform alpha; CKI alpha; CK1; CSNK1A1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Nucleus Accession P48729 Clone Number SDT 2884 60 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample PC 3, Caco 2, MCF7, HeLa, NIH 3T3, mouse spleen, rat brain, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | CK1α |
| Synonyms | Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Nucleus |
| Accession | P48729 |
| Clone Number | SDT-2884-60 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | PC-3, Caco-2, MCF7, HeLa, NIH/3T3, mouse spleen, rat brain, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:100 | Hu |
Background
CK1α (casein kinase 1 isoform alpha) is a ubiquitously expressed, constitutively active serine/threonine kinase that docks to a conserved recognition motif (pSer/pThr-X-X-S/T) in hundreds of cytoplasmic, nuclear and membrane substrates, thereby governing Wnt/β-catenin signaling by phosphorylating β-catenin for β-TrCP-mediated degradation, synchronizing circadian rhythms through PER protein turnover, regulating DNA-damage checkpoints by modifying p53 and MDM2, driving hematopoietic stem-cell maintenance via AKT pathway modulation, and serving as an essential, druggable node whose loss-of-function triggers ribosomal stress and selective apoptosis in acute myeloid leukemia cells.
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