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Description
Cytochrome P450 Recombinant Rabbit mAb (S-3162-29)Product Specification Host Rabbit Antigen Cytochrome P450 Synonyms Cytochrome P450 2E1; 4 nitrophenol 2 hydroxylase; CYPIIE1; Cytochrome P450 J; CYP2E; CYP2E1 Immunogen Synthetic Peptide Location Mitochondrion, Endoplasmic reticulum Accession P05181 Clone Number S 3162 29 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HepG2, HeLa, HaCaT, HEK 293 Predicted Reactivity RhMk, CyMk Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | Cytochrome P450 |
| Synonyms | Cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J; CYP2E; CYP2E1 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion, Endoplasmic reticulum |
| Accession | P05181 |
| Clone Number | S-3162-29 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HepG2, HeLa, HaCaT, HEK-293 |
| Predicted Reactivity | RhMk, CyMk |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
Background
Cytochrome P450 proteins constitute a ubiquitous superfamily of heme-containing mono-oxygenases that orchestrate the regio- and stereoselective insertion of a single oxygen atom into thousands of structurally diverse substrates, leveraging a conserved Fe(II)-protoporphyrin IX center that cycles between ferric, ferrous, and highly reactive Fe(IV)=O (Compound I) states to catalyze reactions ranging from hydroxylation and epoxidation to dealkylation and dehalogenation, thereby governing the phase-I metabolism of approximately 75 % of all pharmaceuticals, detoxifying xenobiotics, synthesizing endogenous signaling molecules such as steroid hormones and eicosanoids, and driving biosynthetic pathways in plants, fungi, and bacteria, while exhibiting remarkable inter-species and inter-individual genetic polymorphisms that underlie variable drug responses, environmental adaptations, and evolutionary diversification across archaea, prokaryotes, and all eukaryotic kingdoms.
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