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Description
SYT2 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen SYT2 Synonyms Synaptotagmin 2; Synaptotagmin IIImported (SytII) Immunogen Synthetic Peptide Location Cytoplasm, Synapse Accession Q8N9I0 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample TT, mouse cerebellum, rat cerebellum Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | SYT2 |
| Synonyms | Synaptotagmin-2; Synaptotagmin IIImported (SytII) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Synapse |
| Accession | Q8N9I0 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | TT, mouse cerebellum, rat cerebellum |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Ms, Rt |
Background
Synaptotagmin-2 (SYT2) is a synaptic vesicle membrane protein that functions as a calcium sensor and plays a crucial role in fast Ca²⁺ -dependent neurotransmitter release at the presynaptic nerve terminal. It is widely expressed in the brain and is particularly important at the neuromuscular junction. SYT2 contains two calcium-binding domains, C2A and C2B, with the C2B domain being essential for mediating vesicle fusion and neurotransmitter release. Mutations in the SYT2 gene can lead to various neuromuscular disorders, such as distal motor neuropathy and myasthenic syndrome, which are often associated with presynaptic dysfunction at the neuromuscular junction. Recent studies have also shown that SYT2 can serve as a reliable marker for analyzing the development and plasticity of inhibitory synapses formed by parvalbumin-positive interneurons in the visual cortex.
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