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Description
Alexa Fluor® 647 Mouse Anti-Human CD185 Antibody (S-R653)Product Specification Host Mouse Antigen CD185 Synonyms C X C chemokine receptor type 5; CXC R5; CXCR 5; Burkitt lymphoma receptor 1; Monocyte derived receptor 15 (MDR 15); BLR1; MDR15; CXCR5 Location Cell membrane Accession P32302 Clone Number S R653 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 02mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid
Product Specification
| Host | Mouse |
| Antigen | CD185 |
| Synonyms | C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15 (MDR-15); BLR1; MDR15; CXCR5 |
| Location | Cell membrane |
| Accession | P32302 |
| Clone Number | S-R653 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.02mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD185, also known as CXCR5 or Burkitt lymphoma receptor 1 (BLR1), is a 42 kD G-protein coupled receptor with seven transmembrane regions. It belongs to the CXC chemokine receptor family and is a specific receptor for the CXC chemokine CXCL13. CD185 is expressed on mature B cells, follicular helper T cells (Tfh), and certain memory T cells. It plays a critical role in lymphocyte trafficking, particularly in the migration of T cells into B cell follicles of germinal centers, making it an established marker of follicular helper T cells. Additionally, CD185 is involved in B cell migration and maturation in lymph nodes and spleen. Its expression has been reported in various tissues, including human blood, salivary glands, and lymphatic organs.
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