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Description
eIF4E Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen eIF4E Synonyms Eukaryotic translation initiation factor 4E; eIF 4E; eIF4E; eIF 4F 25 kDa subunit; mRNA cap binding protein; EIF4EL1; EIF4F Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P06730 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, HeLa, MCF7, K562, NIH 3T3, mouse testis, PC 12, rat testis Predicted Reactivity
Product Specification
| Host | Rabbit |
| Antigen | eIF4E |
| Synonyms | Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; EIF4EL1; EIF4F |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P06730 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, HeLa, MCF7, K562, NIH/3T3, mouse testis, PC-12, rat testis |
| Predicted Reactivity | Bv, Rb, Xe |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
eIF4E（eukaryotic initiation factor 4E）is a crucial eukaryotic translation initiation factor. It plays a key role in the initiation of protein synthesis by recognizing and binding to the 7-methylguanosine cap structure at the 5' end of eukaryotic mRNA. This binding facilitates the recruitment of the ribosome and other initiation factors to the mRNA, thereby promoting the start of translation. eIF4E is highly conserved across different eukaryotic species and is involved in a variety of biological processes such as cell growth, proliferation, and differentiation. Its activity can be regulated by various mechanisms including phosphorylation and interaction with other proteins. Abnormal expression or function of eIF4E has been implicated in several diseases, including cancer, where it may contribute to tumor development and progression by promoting the translation of oncogenic mRNAs.
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