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Description
Fas Ligand/TNFSF6 His Tag Protein, MouseProduct Specification Species Mouse Synonyms CD95LFas ligandSPAFASLGSoluble Fas ligandsFasLReceptor binding FasL ectodomainFasL ICDTNFSF6Apoptosis antigen ligandTumor necrosis factor ligand superfamily member 6APLCD178Fas Ligand (TNF Superfamily Member 6)Fas Antigen LigandCD95 LigandCD95 LAPTLMutant Tumor Necrosis Factor Family Member 6Apoptosis (APO 1) Antigen Ligand 1CD178 AntigenALPS1BTNLG1AFasLFas Ligand ProteinSPPL2A processed FasL
Product Specification
| Species | Mouse |
| Synonyms | CD95L，Fas ligand，SPA，FASLG，Soluble Fas ligand，sFasL，Receptor-binding FasL ectodomain，FasL ICD，TNFSF6，Apoptosis antigen ligand，Tumor necrosis factor ligand superfamily member 6，APL，CD178，Fas Ligand (TNF Superfamily， Member 6)，Fas Antigen Ligand，CD95 Ligand，CD95-L，APTL，Mutant Tumor Necrosis Factor Family Member 6，Apoptosis (APO-1) Antigen Ligand 1，CD178 Antigen，ALPS1B，TNLG1A，FasL，Fas Ligand Protein，SPPL2A-processed FasL form，APT1LG1，Tumor Necrosis Factor (Ligand) Superfamily， Member 6，Tumor Necros，TNFSF6 |
| Accession | P41047-1 |
| Amino Acid Sequence | Pro132-Leu279, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 25-33kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Cell Death Differ . 2012 Jan;19(1):42-50. Epub 2011 Sep 30. |
Background
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigen-stimulated T cells. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include: T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
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