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Description
NMT1 Recombinant Rabbit mAb (S-2986-17)Product Specification Host Rabbit Antigen NMT1 Synonyms Glycylpeptide N tetradecanoyltransferase 1; Myristoyl CoA: protein N myristoyltransferase 1 (HsNMT1; NMT 1; Type I N myristoyltransferase); Peptide N myristoyltransferase 1; Protein lysine myristoyltransferase NMT1; NMT Immunogen Synthetic Peptide Location Cytoplasm Accession P30419 Clone Number S 2986 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk
Product Specification
| Host | Rabbit |
| Antigen | NMT1 |
| Synonyms | Glycylpeptide N-tetradecanoyltransferase 1; Myristoyl-CoA:protein N-myristoyltransferase 1 (HsNMT1; NMT 1; Type I N-myristoyltransferase); Peptide N-myristoyltransferase 1; Protein-lysine myristoyltransferase NMT1; NMT |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P30419 |
| Clone Number | S-2986-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | SK-OV-3, HeLa, NIH/3T3, mouse brain, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
NMT1 is a cytosolic monomeric enzyme that catalyzes the irreversible, co-translational transfer of myristic acid from myristoyl-CoA to the N-terminal glycine of nascent polypeptides, a modification essential for membrane targeting, signal transduction, and stability of oncogenic kinases (e.g., Src, FAK), and its overexpression in cancers promotes proliferation, suppresses autophagy, and supports metabolic reprogramming through specific regulation of AMPKβ myristoylation, making it a validated therapeutic target.
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