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Description
ALPP/ALPPL2 Recombinant Rabbit mAb (S-2089-36)Product Specification Host Rabbit Antigen ALPP ALPPL2 Synonyms Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1 (PLAP 1); PLAP Immunogen Synthetic Peptide Location Cell membrane Accession P05187 Clone Number S 2089 36 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample A431 Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | ALPP/ALPPL2 |
| Synonyms | Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1 (PLAP-1); PLAP |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P05187 |
| Clone Number | S-2089-36 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | A431 |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
ALPP/ALPPL2 proteins are members of the alkaline phosphatase family, which are closely related and regulated GPI-anchored proteins. ALPP, also known as placental alkaline phosphatase, and ALPPL2, also known as germ cell alkaline phosphatase or placental-like alkaline phosphatase 2, share a high degree of amino acid sequence similarity (98% homology) and have a highly restricted tissue expression pattern, primarily found in placental trophoblasts and certain tumor tissues. ALPPL2 is expressed in various cancers, including mesothelioma, ovarian cancer, and gastric cancer, and is considered a tumor-specific antigen due to its high tissue specificity. This makes it a promising target for cancer therapies, such as antibody-drug conjugates and CAR-T cell therapies.
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