SKU: 27118640428

CDKN2A/p16INK4a Recombinant Rabbit mAb (S-2536-38)

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Description

CDKN2A/p16INK4a Recombinant Rabbit mAb (S-2536-38)Product Specification Host Rabbit Antigen p16INK4a Synonyms Cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase 4 inhibitor A (CDK4I); p16 INK4a (p16 INK4); P16ink4a; Cdkn2a Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P51480 Clone Number S 2536 38 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample A20 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Antigen p16INK4a
Synonyms Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A (CDK4I); p16-INK4a (p16-INK4); P16ink4a; Cdkn2a
Immunogen Recombinant Protein
Location Cytoplasm, Nucleus
Accession P51480
Clone Number S-2536-38
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Ms
Positive Sample A20
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:5000 Ms

Background

p16INK4a is a 16 kDa cyclin-dependent kinase inhibitor encoded by the CDKN2A locus on chromosome 9p21 that specifically binds to and inactivates CDK4/6 complexes, thereby preventing phosphorylation of the retinoblastoma protein (pRb) and enforcing a G1 cell-cycle arrest that functions as a critical tumor-suppressive barrier against oncogenic stress; its expression rises sharply with aging and acts as a robust biomarker of cellular senescence across diverse tissues, while its frequent inactivation through deletion, mutation, or promoter hypermethylation is observed in numerous human cancers, underscoring its pivotal role in both aging-related pathophysiology and oncogenesis.

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Exchange/Return Notes
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SKU: 27118640428

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4.4 ★★★★★
Based on 30 reviews
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Chris
Chelsea, US
★★★★★ 5
It's ink and it works.
Style: Ink
It's ink and it works. My Epson printer is VERY finicky and only wants name-brand ink. This is it. A little pricey but they all are.
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Reviewed in the United States on July 4, 2025
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Verified Purchase
ChemProf
Charlottesville, US
★★★★★ 5
Well performing ink for my particular printer
Style: Ink
These inks work well, and are easy to install. They do not last long. They follow the current apparent marketing scheme of offering a a very good printer at a very favorable price, but charging relatively high prices for the ink. I understand that people need to make a profit somewhere.
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Reviewed in the United States on August 13, 2025
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Verified Purchase
HONEST REVIEWER
Belleville, US
★★★★★ 4
Title: Solid, Reliable Ink – No Frills, No Surprises (4 ★)
Style: Ink
The Bottom Line The Epson 822 DURABrite Ultra Ink Standard‑Capacity Black & Color Cartridge Combo Pack (T822120‑BCS) does exactly what it promises: it prints clean, sharp pages on the WorkForce Pro WF‑3820/3823/4820/4830/4833/4834 series with no hiccups. It isn’t a game‑changing breakthrough, but it’s dependable enough that you can toss it in your cart, try it out, and feel confident you won’t be left with a printer jam or faded text. Why I Gave It Four Stars Aspect Verdict Comments Performance ★★★★★ Prints consistently on both black and color pages. Colors are vivid, blacks are deep, and there are no streaks or banding. Compatibility ★★★★★ Works flawlessly with all the WorkForce Pro models listed on the box. No driver updates or firmware tricks needed.Value ★★★★☆ Standard‑capacity cartridges are a bit pricier than high‑yield options, but you get the expected page yields (≈ 2,000 B / 1,800 C / M / Y). Packaging & Arrival ★★★★★ Packaged securely, the “OME” seal was intact, and the cartridges arrived ready to install. Innovation ★★☆☆☆ Nothing revolutionary – just solid, reliable ink. If you’re looking for a “wow” factor, this isn’t it. Return Policy ★★★★★ Amazon’s 30‑day liberal return policy makes the purchase low‑risk; you can always send it back if it doesn’t meet your expectations. Overall, the combo earns a four‑star rating because it meets every functional requirement without any drama, but it also doesn’t exceed expectations enough to merit a perfect score. What I Actually Did Unboxed the combo and confirmed the “OME” seal was intact – a quick visual check that the cartridges weren’t tampered with. Installed the black cartridge first, then the four color cartridges, following the printer’s on‑screen prompts. Ran a printer self‑test and printed a few typical office documents (reports, spreadsheets, a color flyer). Checked the print quality side‑by‑side with my old OEM cartridges. The results were virtually identical – no ghosting, no color shifts. Pros Plug‑and‑play: No quirks, no firmware hacks. Consistent quality: Straight‑forward, vibrant colors and clean blacks. Reliable supply: Works across the entire WorkForce Pro lineup mentioned. Risk‑free purchase: Amazon’s 30‑day return window lets you test without commitment. Cons Standard capacity only: If you print heavily, the higher‑yield (XL) versions would be more economical. No “wow” factor: It’s a solid, work‑horse cartridge, not a revolutionary ink formula. Price: Slightly higher than some off‑brand alternatives, though you pay for brand reliability. Who Should Consider This Home‑office users who need dependable daily printing without fuss. Small businesses that run a mix of black‑and‑white documents and occasional color marketing pieces. Anyone who values a hassle‑free experience and appreciates a generous return policy as a safety net. If you’re hunting for an ink set that will wow you with cutting‑edge technology, look elsewhere. If you just want a cartridge that does its job, lasts as expected, and won’t surprise you with printer errors, the Epson 822 DURABrite Ultra combo is a safe bet. Bottom line: It’s a reliable, as‑described product that earns my respect, just not my awe. Four stars—good enough to recommend, but not enough to call it a breakthrough.
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Reviewed in the United States on March 4, 2026
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Verified Purchase
ben amarante
Waukegan, US
★★★★★ 5
Very good product and thanks for quality service.
Style: Ink
Arrived on time, good product and quality service. Thanks, and will buy again in the future.
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Reviewed in the United States on May 14, 2026
A
Verified Purchase
Amazon Customer
Birmingham, US
★★★★★ 5
Fast Delivery
Style: Ink
Fast delivery. Easy to install.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 12, 2026

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