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Description
FOXG1 Recombinant Rabbit mAb (S-1319-230)Product Specification Host Rabbit Antigen FOXG1 Synonyms Forkhead box protein G1; Brain factor 1 (BF 1; BF1); Brain factor 2 (BF 2; BF2; hBF 2); Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C Immunogen Synthetic Peptide Location Nucleus Accession P55316 Clone Number S 1319 230 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | FOXG1 |
| Synonyms | Forkhead box protein G1; Brain factor 1 (BF-1; BF1); Brain factor 2 (BF-2; BF2; hBF-2); Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P55316 |
| Clone Number | S-1319-230 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | mouse E14 brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
FOXG1 (Forkhead box G1) is a winged-helix transcription factor essential for vertebrate forebrain development, acting as a pioneer factor that opens chromatin and orchestrates the earliest steps of telencephalon specification by repressing dorsalizing genes, promoting FGF8 expression, and directing the temporal progression of cortical progenitor proliferation, neuronal layer fate transitions, oligodendrocyte maturation and postnatal myelination through dosage-sensitive interactions with morphogen signals, histone-modifying complexes and post-translational phosphorylation that control its nuclear–cytoplasmic shuttling, so that even modest alterations in FOXG1 levels produce a spectrum of neurodevelopmental disorders ranging from microcephaly and corpus callosum agenesis to severe encephalopathy with autism-like behaviors.
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