SKU: 28673692880

PCSK9 Recombinant Rabbit mAb (SDT-424-252)

Sale price$375.75 Regular price$417.50
Save 10%

Pay in installments of $104.38 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Sep 8 - Sep 13

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

PCSK9 Recombinant Rabbit mAb (SDT-424-252)Product Specification Host Rabbit Synonyms Neural apoptosis regulated convertase 1 (NARC 1); Proprotein convertase 9 (PC9); Subtilisin kexin like protease PC9 Immunogen Recombinant Protein Accession Q8NBP7 Clone Number SDT 424 252 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize CHI3L1 Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Synonyms Neural apoptosis-regulated convertase 1 (NARC-1); Proprotein convertase 9 (PC9); Subtilisin/kexin-like protease PC9
Immunogen Recombinant Protein
Accession Q8NBP7
Clone Number SDT-424-252
Antibody Type Recombinant mAb
Isotype IgG
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity Does not recognize CHI3L1
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

Na-citrate, pH 6.0, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

PCSK9 is ubiquitously expressed in many tissues and cell types. PCSK9 binds to and degrades the receptor for low-density lipoprotein particles (LDL), which typically transport 3,000 to 6,000 fat molecules (including cholesterol) per particle, within extracellular fluid. The LDL receptor (LDLR), on liver and other cell membranes, binds and initiates ingestion of LDL-particles from extracellular fluid into cells and targets the complex to lysosomes for destruction. If PCSK9 is blocked, the LDL-LDLR complex separates during trafficking, with the LDL digested in the lysosome, but the LDLRs instead recycled back to the cell surface and so able to remove additional LDL-particles from the extracellular fluid. Therefore, blocking PCSK9 can lower blood LDL-particle concentrations. PCSK9 has medical importance because it acts in lipoprotein homeostasis. Agents that block PCSK9 can lower LDL particle concentrations. The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated. PCSK9 inhibitors are promising therapeutics for the treatment of people who exhibit statin intolerance, or as a way to bypass frequent dosage of statins for higher LDL concentration reduction. So, measurement of plasma PCSK9 level will be more useful for monitoring treatment effect.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 28673692880

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 24 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
I
Verified Purchase
Isabel clara
Bozeman, US
★★★★★ 5
Dream big
Format: Kindle
What a great collection of books if you have that dream of starting your own business and you don't know where to start, these books are ideal for you. They will guide you with actionable tips and step-by-step strategies and include real-world examples of how to achieve that dream of being your own boss. What I liked the most are the real-world success stories that the author includes, the stories serve as motivation. Each success story told is a lesson with practical ideas that will help you better understand the steps and tools you need to achieve your dream. I found it very interesting that if the first book in the collection serves to guide you on how to start your business, in the second book the author will help you prepare for digital marketing, explaining that you should keep yourself updated with new trends, acquiring knowledge of where to invest and when, and most importantly that your business incorporates the latest AI tools to be more productive. These are some 💎 gems of books, these books serve as motivational guides with the tools and concepts that will help guide you on the path you need to take to achieve the business you dream of, I recommend it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 11, 2025
Y
Verified Purchase
Yanny
Belleville, US
★★★★★ 5
Start your business
Format: Kindle
This is such a great deal. You get teo books in one. If you are looking to start a business, but not sure where to start this guide has you covered. Part two of the book takes you into the digital marketing , to help grow your business. Marketing is very important in getting clients and keeping them. Starting a business might feel overwhelming or intimidating, but it doesnt have to be. This book will help you navigate complex concepts, find the best suited structure for your business, funds to get started, and your marketing strategy. This 2 in 1 guide is such a helpful tool for starting a business.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 6, 2025
S
Verified Purchase
ShariC
Lake Worth, US
★★★★★ 5
Success Guide on Securing Capital and Building a Profitable Customer Base
Format: Kindle
This comprehensive guide is a must-have for aspiring entrepreneurs. Covering both securing capital and building a loyal customer base, it provides actionable strategies to turn your business vision into a thriving reality. With expert advice on funding options, marketing tactics, and customer retention, this book simplifies the complexities of starting and growing a business. Whether you're launching your first venture or looking to refine your entrepreneurial skills, this 2-in-1 guide equips you with the tools and knowledge to succeed in today’s competitive market.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 6, 2025
T
Verified Purchase
tricia
Boise, US
★★★★★ 4
Business owners
Format: Kindle
Great 2-1 book to increase your business skills with easy to read great information on digital marketing,and branding your product. Recommended this book for anyone that wants the most out of your business.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 16, 2025
H
Verified Purchase
Heidi Augustine
Grantham, US
★★★★★ 5
Amazing information
Format: Kindle, Format: Kindle
Wow, what a fantastic book for how to start business and for it to be successful. There is great advice, resource, tips and tricks, the dos and donts of to have a successful business. Talks about a business plan and not all business plans will work for each business. There is alot of valuable information and tools on how to run your own business. If you are wanting to start up your own business/be your own boss then this book is definitely for you. I definitely recommend this book
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 20, 2025

recommand products