SKU: 29275671909

Phospho-TrkA (Tyr490)/TrkB (Tyr516) Recombinant Rabbit mAb (S-3812)

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Description

Phospho-TrkA (Tyr490)/TrkB (Tyr516) Recombinant Rabbit mAb (S-3812)Product Specification Host Rabbit Antigen Phospho TrkA (Tyr490) TrkB (Tyr516) Synonyms High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type; Tyrosine kinase receptor; TRK Location Endosome, Cell membrane Accession P04629Q16620 Clone Number S 3812 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Rt Positive Sample NGF treated PC 12 Purification Protein A Concentration 0. 5 mg ml Conjugation

Product Specification


Host Rabbit
Antigen Phospho-TrkA (Tyr490)/TrkB (Tyr516)
Synonyms High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type; Tyrosine kinase receptor; TRK
Location Endosome, Cell membrane
Accession P04629、Q16620
Clone Number S-3812
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Rt
Positive Sample β-NGF treated PC-12
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Rt

Background

Phospho-TrkA (Tyr490) and phospho-TrkB (Tyr516) are the neurotrophin-activated, autophosphorylated forms of the receptor tyrosine kinases TrkA and TrkB; once these juxtamembrane tyrosines are phosphorylated they serve as docking platforms for adaptor proteins—TrkA-pTyr490 recruits FRS2 and Shc to trigger Ras/MAPK and PI3K/Akt cascades that mediate neuronal survival and differentiation, whereas TrkB-pTyr516 binds Shc to activate the same pathways plus PLCγ-driven PKC and Ca²⁺ signals that regulate synaptic plasticity—so antibodies detecting these phospho-sites are widely used as biomarkers for NGF- or BDNF-dependent Trk signaling in health and disease.

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SKU: 29275671909

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4.5 ★★★★★
Based on 9 reviews
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Product Reviews
E
Verified Purchase
Elizabeth Hills
Dallas, US
★★★★★ 5
Love love love Robeez. Best soft soled shoes for baby/toddler just learning to walk.
Size: 12-18 Months Toddler, Color: Grey Leather
I can’t even tell you how much I love these shoes for my kids. My oldest son born 2018 had a pair of Robeez, the shark kind, and I’ve passed them down through all my boys until now- now somehow one of them has gone missing, still looking. So we got these for baby and oh my gosh Robeez has upped their game! The soles are still soft enough to be pliable but have some structure to them, they fit softly enough to accommodate round chubby feet but again have some structure, and they look adorable. The quality is really high and that’s so wonderful to see this day and age when so many things are produced cheaply. These are truly lovely. And they’re very handsome. My sweet boy wore them to a birthday party at the park and they were a hit. I love this brand so much, and these shoes are so cute. I wish I were having more kids to buy more cute pairs :)
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 26, 2025
J
Verified Purchase
Jennifer R.
Dallas, US
★★★★★ 5
The Perfect First Shoe! Worth the Price.
My little one was just starting the stand/learning to walk and we wanted something to protect his feet while we were out of the house. Since babies/toddlers grow out of their shoes so quickly, I tried desperately to find shoes that didn't cost more than $20. However, I tried about 6 different "cheaper" shoes, all different brands, and nothing would stay on my babies feet. I finally broke down and bought these shoes and they are perfect. I ended up wasting more money trying not to spend too much money on shoes that would be too small after a couple months. It would have been cheaper for me to just buy these shoes to start. Fit wise they are great. Super easy to put on. They stay on! I appreciate the rubber portion on the sole because it gave my little one more traction when he was learning to walk. They are light way and the sole is very flexible which is important for the proper development of their feet. I just wish they made larger sizes because I am going to have to start the hunt all over for the perfect shoe once he grows out of the biggest size that Robeez sells. Save yourself time and avoid wasting money on shoes that don't stay on. Just buy these shoes!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 28, 2023
E
Verified Purchase
Elle
Grantham, US
★★★★★ 5
Cute and STABLE
Size: 12-18 Months Toddler, Color: Navy Leather
This brand was recommended by a family member as being good for kids who are learning how to walk, and I definitely agree. My son had a different pair of shoes from Carter’s that fit well and looked cute, but the soles were a little too slick for an early walker despite having little rubberized dots on them. I like that these have more realistic soles, with real traction and support, but still allow the kid’s foot to flex. My son is very comfortable in them and was immediately noticeably more stable while standing and practicing walking in them. Bonus- they are super cute and this design is neutral enough to go with plenty of his clothes. My only small complaint is a little thread coming loose on one shoe, but so far it isn’t causing any issues/doesn’t seem to be unraveling anything structural. Highly recommend overall!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2022
C
Verified Purchase
ChrissyD
Pawtucket, US
★★★★★ 4
Great shoes!
Size: 18-24 Months Toddler, Color: Grey Leather
Love these shoes, only shoes I put my 15 month old in. However, they do run small. I bought 12-18 month size and my boy out grew them before 12 months old, I had to repurchase 18-24m to fit perfectly.
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Reviewed in the United States on November 8, 2025
E
Verified Purchase
Emily
Lexington, US
★★★★★ 5
The BEST toddler shoe!!
Size: 18-24 Months Toddler, Color: Brooks Grey Leather
These shoes are 100% worth every penny. They are super easy to get on and off due to the fact that the tongue pulls back fully and they are flexible yet sturdy. They are excellent quality and have maintained great condition with my busy toddler at the park. The wide toe box provides great comfort for my little one’s wide feet. Buy the shoes!!!
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Reviewed in the United States on September 4, 2025

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