SKU: 29639096782

TACC3 Recombinant Rabbit mAb (S-3048-50)

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Description

TACC3 Recombinant Rabbit mAb (S-3048-50)Product Specification Host Rabbit Antigen TACC3 Synonyms Transforming acidic coiled coil containing protein 3; ERIC 1; ERIC1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession Q9Y6A5 Clone Number S 3048 50 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample RPMI 8226, HeLa, Raji, Ramos, mouse testis, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation

Product Specification


Host Rabbit
Antigen TACC3
Synonyms Transforming acidic coiled-coil-containing protein 3; ERIC-1; ERIC1
Immunogen Synthetic Peptide
Location Cytoplasm, Cytoskeleton
Accession Q9Y6A5
Clone Number S-3048-50
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample RPMI-8226, HeLa, Raji, Ramos, mouse testis, rat testis
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:1000 Hu, Ms, Rt
ICC 1:500 Hu

Background

TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a centrosomal and microtubule-associated protein essential for bipolar spindle assembly and chromosome segregation during mitosis and meiosis. It stabilizes microtubules by forming a complex with ch-TOG (CKAP5) and clathrin, promoting kinetochore-microtubule attachments and preventing spindle multipolarity. TACC3 is frequently overexpressed or involved in oncogenic fusions like FGFR3-TACC3 in various cancers, including bladder, pancreatic, and colorectal cancers, where it drives proliferation, immune evasion, and chemoresistance. Its overexpression disrupts DNA damage response pathways and sensitizes cells to PARP inhibitors, while its depletion induces mitotic catastrophe and cell cycle arrest, making it a promising therapeutic target in oncology.

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SKU: 29639096782

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4.4 ★★★★★
Based on 5 reviews
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C
Verified Purchase
CSI AJ
Lexington, US
★★★★★ 4
Warm, comfortable booties
Size: 12-13, Color: Red/Black Check
I would give these booties a 5 star because they are soft, warm, comfortable, high on my ankle and a color I appreciate. They are easy to slip on NOW. I say "NOW" because I have a deformed foot due to being broken. That foot was hard to get the bootie on. After 1 try in which some of the stitching came out; it's easy to put on. The stitching came out far to easily. There are 3 lines of stitching. One line between the sole and 1st layer of polar fleece. That line has had no problem. The other 2 lines have each come out abt 3 inches. I got size 12
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 17, 2026
R
Verified Purchase
R Secrest
Los Angeles, US
★★★★★ 5
Very Warm and Comfortable
Size: 12-13, Color: Red/Black Check
Love these. Just like walking on a cloud. They are very warm. Note there is no L or R, fits either foot.
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Reviewed in the United States on April 30, 2026
G
Verified Purchase
Geobub
Dallas, US
★★★★★ 3
Seams Separate Quickly
Size: 8-9, Color: Red/Black Check
They fall apart. The seams are terrible and almost immediately separate. Although they are warm and comfortable until stuff comes through the separated seams.
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Reviewed in the United States on March 29, 2026
D
Verified Purchase
David Pritchett
Cuba, US
★★★★★ 5
Meeting my expectations....
Size: 14-15, Color: Grey/White Check
I am a male with pretty large feet (Mens size 14US) and wanted some very warm slippers to wear around the house. I have nerve issues in my toes and if I don't keep my feet very warm they start to hurt. I wanted something both comfortable and warm. I received these a few days ago and so far they have done a great job at keeping my feet warm. The linings are thick and fluffy and the bottoms feel like they have a memory foam inner sole in them. The tops can either be worn up or rolled down. The actual soles are a soft leather-like material. They are thicker than normal cloth, but not hard like rubber soled slippers (I actually wanted something that was more of a slipper and less of a "shoe"). The only down side is that they don't really seem to have a left and right to them (both slippers seem identical), and for awhile no matter how I wore them, they felt a bit like they were on the wrong feet. However, they seem to have formed themselves to my feet and now (through wearing them) it definitely feels like there is a left and a right. I don't know how long these will last, but they were not expensive, so if I get a few months of wear from them, I will be happy and will just order another pair when these wear out. They aren't the most attractive slippers in the world, but they aren't horrible looking and they are very functional.
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Reviewed in the United States on February 24, 2025
J
Verified Purchase
John Palmer
West Palm Beach, US
★★★★★ 4
for polar fleece slippers with leather soles, these are quite nice
Size: 8-9, Color: Red/Black Check
I bought these to replace some Mug Lugs slippers last fall after they had started to come apart from barely a year of use (they were knitted) and have been wearing them constantly since then. The polar fleece does easily pill somewhat but get a hard use and are quite comfortable too. I wear these in the house most of the time as my feet do not like to wear shoes all day. They are comfortable, and do seem to hold up well. The only other issue is until I get my office chair mat replaced, these catch and can cause problems and have a little, but not enough to worry too much about. They supposedly have an anti slip design on the bottom, but if flour falls on the kitchen floor, not so slip resistant. I chose these as one, they are red, but also plaid and like them a lot. Hopefully, I get more than a years use out of them. I have had several polar fleece sock type slippers similar to these in the past, and the last polar fleece pair in Dk Blue and from Land End finally after several years of constant use, the stitching began to come apart and the sole was separating from the body of the slipper on one slipper. They do keep the feet warm, with or without socks and can, at times, get my feet too warm but I enjoy them quite a bit.
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Reviewed in the United States on May 3, 2025

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