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Description
LIF Protein, BovineProduct Specification Species Bovine Synonyms LIF; Leukemia Inhibitory Factor Protein; CDF Protein; DIA Protein; HILDA Protein; MLPLI Protein; D Factor; DIA; differentiation inhibitory activity; differentiation stimulating factor; Differentiation stimulating factor; Emfilermin; LIF; Melanoma derived LPL inhibitor; MLPLI Accession Q27956 Amino Acid Sequence Ser23 Phe202 Expression System E. coli Molecular Weight 19. 8 kDa (Reducing) Purity >95% by SDS
Product Specification
| Species | Bovine |
| Synonyms | LIF; Leukemia Inhibitory Factor Protein; CDF Protein; DIA Protein; HILDA Protein; MLPLI Protein; D Factor; DIA; differentiation inhibitory activity; differentiation stimulating factor; Differentiation-stimulating factor; Emfilermin; LIF; Melanoma-derived LPL inhibitor; MLPLI |
| Accession | Q27956 |
| Amino Acid Sequence | Ser23-Phe202 |
| Expression System | E.coli |
| Molecular Weight | 19.8 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Salas EM, et al. (2011) LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. Genes Cancer. 2 (5): 593-6. |
Background
LIF (leukemia inhibitory factor) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone metabolism, cachexia, neural development, embryogenesis, and inflammation. The first exon encoding the signal sequence is alternately spliced, resulting in LIF-D, LIF-M, and LIF‑T mRNAs that produce secreted, extracellular matrix‑associated, and intracellular forms, respectively. LIF has potent proinflammatory properties, being the inducer of the acute phase protein synthesis and affecting cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic, and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal-transducing subunit. This leads to the activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origins.
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