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Description
IL-1RAcP/IL-1R3 Fc Chimera protein, Cynomolgus/Rhesus macaqueProduct Specification Species Cynomolgus Synonyms Interleukin 1 receptor 3, IL 1RAcP, IL 1 receptor accessory protein, IL 1R 3, C3orf13, Interleukin 1 Receptor Accessory Protein, IL1R3, Interleukin 1 Receptor Accessory Protein Beta, IL 1R3 Accession P59822 1 Amino Acid Sequence Ser21 Glu359, with C hIgG Fc Expression System HEK293 Molecular Weight 75 90kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated
Product Specification
| Species | Cynomolgus |
| Synonyms | Interleukin-1 receptor 3, IL-1RAcP, IL-1 receptor accessory protein, IL-1R-3, C3orf13, Interleukin 1 Receptor Accessory Protein, IL1R3, Interleukin-1 Receptor Accessory Protein Beta, IL-1R3 |
| Accession | P59822-1 |
| Amino Acid Sequence | Ser21-Glu359, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 75-90kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Goldbach-Mansky R. et al. (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol. 124(6): 1141-1149. |
Background
Interleukin-1 receptor accessory protein (IL1RAP or IL-1RAcP) is also known as Interleukin-1 receptor 3 (IL-1R-3 or IL-1R3), C3orf13, which belongs to the interleukin-1 receptor family. It serves as a non-ligand-binding component of the receptors for IL-1 alpha, IL-1 beta, IL-33, and IL-36. Mature human IL-1 RAcP consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 182 aa cytoplasmic domain. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD.
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