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Description
SHARPIN Recombinant Rabbit mAb (S-2356-308)Product Specification Host Rabbit Antigen SHARPIN Synonyms Sharpin; Shank associated RH domain interacting protein; Shank interacting protein like 1 (hSIPL1); SIPL1 Immunogen Synthetic Peptide Location Cytoplasm, Synapse Accession Q9H0F6 Clone Number S 2356 308 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample PC 3, MCF7, T 47D, Raji, U 2 OS, A20, mouse brain, rat testis, COS 7 Predicted
Product Specification
| Host | Rabbit |
| Antigen | SHARPIN |
| Synonyms | Sharpin; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1 (hSIPL1); SIPL1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Synapse |
| Accession | Q9H0F6 |
| Clone Number | S-2356-308 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | PC-3, MCF7, T-47D, Raji, U-2 OS, A20, mouse brain, rat testis, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
SHARPIN (Shank-associated RH domain-interacting protein) is a ~34 kDa ubiquitin-like adaptor that forms the LUBAC complex with HOIP and HOIL-1L to catalyze M1-linked linear ubiquitination of NEMO and other substrates, thereby activating canonical NF-κB signaling, suppressing TNF-α-induced apoptosis, modulating integrin activation, stabilizing β-catenin and ERα to drive Wnt/estrogen-dependent transcription, inhibiting ferroptosis via the p53/SLC7A11/GPX4 axis, promoting Rap1-mediated melanoma metastasis, and regulating Aβ phagocytosis and NLRP3 inflammasome activity in macrophages, with its dysregulation linked to chronic dermatitis, autoimmunity, and cancers of breast, stomach, and skin.
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Exchange/Return Notes
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