SKU: 44285692766

Haptoglobin Recombinant Rabbit mAb (SDT-339-45)

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Description

Haptoglobin Recombinant Rabbit mAb (SDT-339-45)Product Specification Host Rabbit Antigen Haptoglobin Immunogen Recombinant Protein Accession P00738 Clone Number SDT 339 45 Antibody Type Rabbit mAb Application Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize Hemoglobin Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt

Product Specification


Host Rabbit
Antigen Haptoglobin
Immunogen Recombinant Protein
Accession P00738
Clone Number SDT-339-45
Antibody Type Rabbit mAb
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity Does not recognize Hemoglobin
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds with high affinity to free hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to free heme. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels. Haptoglobin, in its simplest form, consists of two alpha and two beta chains, connected by disulfide bridges. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. Hp exists in two allelic forms in the human population, so-called Hp1 and Hp2, the latter one having arisen due to the partial duplication of Hp1 gene. Three genotypes of Hp, therefore, are found in humans: Hp1-1, Hp2-1, and Hp2-2. Hp of different genotypes have been shown to bind hemoglobin with different affinities, with Hp2-2 being the weakest binder. Hemoglobin that has been released into the blood plasma by damaged red blood cells has harmful effects. The HP gene encodes a preproprotein that is processed to yield both alpha and beta chains, which subsequently combines as a tetramer to produce haptoglobin. Haptoglobin functions to bind the free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Most attention has been paid to determining haptoglobin phenotype as a genetic fingerprint used in forensic medicine. More recently, several functional differences between haptoglobin phenotypes have been demonstrated that appear to have important biological and clinical consequences. Haptoglobin polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases, including infections, atherosclerosis, and autoimmune disorders. These effects are explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis. Recent evidence is growing that haptoglobin is involved in the immune response as well. The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology.

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SKU: 44285692766

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4.2 ★★★★★
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Product Reviews
J
Verified Purchase
J. Bush
New York, US
★★★★★ 5
Bigger, louder, crinklier, softer, than expected!
Size: X-Large, Color: Rabbit
My dog was gifted a collection of used toys and he really likes a very long stuffed pig which, unfortunately, another dog that is a destructive chewer, totally destroyed. I decided to break down and buy him another long stuffed toy today and since he's always blissfully watching rabbits in the yard and neighborhood I chose the rabbit version. This thing is huge which is great for him- he's 62 lbs and 7 months old and only half grown. He loves it, it has multiple LOUD squeakers, lots of crinkly spots, and fun ears/legs to grab hold off. He's a big fan and it's made with K9 Tuff Guard which LASTS. Super soft and easy to wash. Update after 2 months- easy to wash and looks new after a washing. very durable so far, standing up to indoor and outdoor use. He is not a destructive chewer but whips them around, tramples on them, steps on them while running top speed and chomps on the annoying squeaker for hours. one squeaker has a hole and its tune is now slightly muted (thank god)
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 24, 2019
D
Verified Purchase
Debbie Kielan
Natrona Heights, US
★★★★★ 1
Had big hole in it
Color: Perching Perfection, Size: 7.5" x 6.75" x 6"
This toy had a hole in it when I got it. Like they missed a seam. I meant to return it. But I had a lot going on and forgot to. My dog loved it when I showed it to him. I handed it to him then realized it had a big hole and I had to take it away. Poor guy. He really wanted it.
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Reviewed in the United States on February 25, 2026
M
Verified Purchase
Melinda Rimini
New York, US
★★★★★ 1
STEER CLEAR
Color: Can’T Be Tamed, Size: 9.5" h x 8" w x 4.5" d, Color: Can’T Be Tamed, Size: 9.5" h x 8" w x 4.5" d
Very thin and cheaply made! Same brand sold in Sam's Club in a 3-pack was of much better quality! Steer clear of these!!
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Reviewed in the United States on May 29, 2026
W
Verified Purchase
W. Grubbs
Carnegie, US
★★★★★ 1
Not sewn together well
Color: Can’T Be Tamed, Size: 9.5" h x 8" w x 4.5" d, Color: Can’T Be Tamed, Size: 9.5" h x 8" w x 4.5" d
Back seam ripped open within the first 30 seconds of giving it to my dog.
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Reviewed in the United States on March 5, 2026
L
Verified Purchase
Lauren
Louisville, US
★★★★★ 3
Puppy loves! Supposed to be part of a set though??
Style: Coconut Tree
Bought this simply because we named our puppy Coco and was on a roll ordering her toys… she ended up absolutely LOVING this tiny palm tree!! Maybe because of the size and she was able to really handle it, she takes it everywhere with her and loves the squeaker. HOWEVER, the item is a lot smaller than I expected when ordering for almost $10 and the plastic packaging it came in says “not intended for individual sale, part of a pack” so I would not purchase from this seller again. I will maybe try to find this included with the intended set of toys.
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Reviewed in the United States on May 28, 2022

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