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Description
IL-33 Protein, MouseProduct Specification Species Mouse Synonyms Interleukin 33 protein; IL 33 protein; Interleukin 33; IL 33; IL33; C9orf26; NKHEV; Interleukin 1 family member 11; DVS27; NF HEV and IL 1F11 Accession Q8BVZ5 Amino Acid Sequence Ser109 Ile266 Expression System E. coli Molecular Weight 18kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM PB, 300mM NaCl,
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-33 protein; IL-33 protein;Interleukin 33; IL-33; IL33; C9orf26; NKHEV; Interleukin-1 family member 11; DVS27; NF-HEV and IL- 1F11 |
| Accession | Q8BVZ5 |
| Amino Acid Sequence | Ser109-Ile266 |
| Expression System | E.coli |
| Molecular Weight |
18kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM PB, 300mM NaCl, pH6.5 |
| Reconstitution |
|
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Immunol Rev. 2018 Jan;281(1):154-168. 2. Cytokine. 2022 Sep:157:155961. Epub 2022 Jul 14. |
Background
Interleukin-33 (IL-33) is a tissue-derived nuclear cytokine from the IL-1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells, both during homeostasis and inflammation. It functions as an alarm signal (alarmin) released upon cell injury or tissue damage to alert immune cells expressing the ST2 receptor (IL-1RL1). The major targets of IL-33 in vivo are tissue-resident immune cells such as mast cells, group 2 innate lymphoid cells (ILC2s) and regulatory T cells (Tregs). Other cellular targets include T helper 2 (Th2) cells, eosinophils, basophils, dendritic cells, Th1 cells, CD8+ T cells, NK cells, iNKT cells, B cells, neutrophils and macrophages. IL-33 exhibits pleiotropic function in inflammatory diseases and particularly in cancer. IL-33 may play a dual role as both a pro-tumorigenic and anti-tumorigenic cytokine, dependent on tumor and cellular context, expression levels, bioactivity and the nature of the inflammatory environment
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