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Description
STUP1/CHIP His Tag Protein, HumanProduct Specification Species Human Synonyms CHIP, PP1131, STUB1, E3 ubiquitin protein ligase CHIP, Antigen NY CO 7 Accession Q9UNE7 Amino Acid Sequence Ser23 Tyr303 with His Tag at the N Terminus Expression System E. coli Molecular Weight 33 43kDa (Reducing) Purity 95% by SDS PAGE,> 90% by HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 50mM Tris, 150mM NaCl, pH7. 5, 1mM DTT, 10%Glycerol Stability & Storage Stable
Product Specification
| Species | Human |
| Synonyms | CHIP, PP1131, STUB1, E3 ubiquitin-protein ligase CHIP, Antigen NY-CO-7 |
| Accession | Q9UNE7 |
| Amino Acid Sequence | Ser23-Tyr303 with His Tag at the N-Terminus |
| Expression System | E.coli |
| Molecular Weight | 33-43kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE,> 90% by HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 50mM Tris, 150mM NaCl, pH7.5, 1mM DTT, 10%Glycerol |
| Stability & Storage |
Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles. |
| Reference | 1. Ballinger, C.A., et al. (1999). Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Molecular and Cellular Biology, 19(6), 4535-4545. |
Background
STUB1 (STIP1 Homology and U-Box Containing Protein 1), commonly known as CHIP (C-terminus of Hsc70 Interacting Protein), is a crucial dual-function protein in cellular proteostasis. It serves as both a co-chaperone and an E3 ubiquitin ligase. As a co-chaperone, it binds to the molecular chaperones Hsp70/Hsc70 and Hsp90 via its N-terminal tetratricopeptide repeat (TPR) domain, assisting in client protein folding and stabilization. Its central role lies in its C-terminal U-box domain, which confers E3 ubiquitin ligase activity. This unique combination allows CHIP to ubiquitinate misfolded or damaged client proteins that are delivered by the chaperones, thereby targeting them for proteasomal degradation. It is a central component of the Protein Quality Control (PQC) system, clearing toxic protein aggregates and maintaining proteome integrity.Dysregulation of CHIP function is linked to various human diseases. Loss-of-function mutations or reduced expression are associated with neurodegenerative disorders (e.g., spinocerebellar ataxia, Alzheimer's, Parkinson's) due to defective clearance of pathogenic proteins like tau and α-synuclein. Conversely, its role in degrading oncogenic clients (e.g., HER2, c-Myc) positions it as a potential tumor suppressor in certain cancers. It also plays key roles in aging, cardiac function, and immune responses, making it a significant therapeutic target.
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4.2 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
Good, Comfortable Fit
Size: Medium, Color: (100) White / White / Black, Number of Items: 6, Size: Medium, Color: (100) White / White / Black, Number of Items: 6
I wear a women’s size 9.5 and I got a size Medium. They fit perfect, they aren’t super heavy, but have cushion where needed. Perfect for my steel toe boots
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Reviewed in the United States on May 28, 2026
★★★★★ 5
Son loves them!
Size: Large, Color: Black (6-pairs), Number of Items: 6
My son loves these socks! Comfy, good quality.
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Reviewed in the United States on May 20, 2026
★★★★★ 5
Good fabric
Size: Medium, Color: White, Number of Items: 6
Nice socks. Would buy again.
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Reviewed in the United States on March 23, 2026
★★★★★ 4
Quality and durable socks
Size: Large, Color: White (6-pairs), Number of Items: 6
Great quality socks. This pack was a lot taller on the cuff and bigger than previous batches I have had. Not sure what the change was, but giving it 4 instead of 5 because I preferred the smaller shorter ones they previously made. But these are great quality socks, and last a long time.
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Reviewed in the United States on February 8, 2026
★★★★★ 5
A Game-Changer for Comfort
Size: Medium, Color: Black, Number of Items: 6
I recently upgraded my workout gear with the Under Armour Training Cotton Quarter Socks, and I must say, these socks have revolutionized my exercise experience. Comfortable, durable, and stylish, they truly stand out in the crowded world of athletic socks.
First and foremost, the comfort level of these socks is unparalleled. The blend of cotton and synthetic materials provides a soft and plush feel against my feet, making every step a pleasure. The quarter length strikes the perfect balance, offering ample coverage without being too restrictive or too short. It's like walking on clouds, even during the most intense workouts.
One of the standout features is the moisture-wicking technology. I've worn these socks during high-intensity cardio sessions, and they have consistently kept my feet dry and comfortable. The breathability is remarkable, preventing that uncomfortable feeling of sweaty feet that often accompanies strenuous workouts. No more distractions – just focus on pushing through your fitness routine.
Durability is another strong suit of these socks. After numerous washes, they maintain their shape and elasticity, showing no signs of wear and tear. The reinforced heel and toe areas provide extra support, ensuring longevity and preventing the dreaded sock holes that often plague other brands.
The sleek design of the Under Armour Training Cotton Quarter Socks adds a touch of style to my workout attire. The subtle logo and choice of colors make them versatile enough to pair with any athletic shoes. Whether you're hitting the gym, going for a run, or simply running errands, these socks seamlessly blend fashion with function.
In terms of sizing, I found that they fit true to size. The elastic band around the arch provides a snug yet comfortable fit, ensuring that the socks stay in place throughout any activity.
While the price point may be slightly higher than some other options on the market, the quality and performance of the Under Armour Training Cotton Quarter Socks more than justify the investment. When it comes to comfort, durability, and style, these socks have become an indispensable part of my workout wardrobe.
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Reviewed in the United States on January 3, 2024