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Description
Invivo Anti-Human CD4 Recombinant mAbProduct Specification Host Rat Antigen CD4 Synonyms T cell surface glycoprotein CD4; T cell surface antigen T4 Leu 3 Location Cell membrane Accession P01730 Clone Number S 3691 Antibody Type Rat mAb Isotype Mouse IgG2b,k Application ELISA, FCM, in vitro blocking of CD4+ T cell activation, in vitro CD4 blockade Reactivity Hu Purification Protein G Concentration 5 mg ml Purity >95%(Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated
Product Specification
| Host | Rat |
| Antigen | CD4 |
| Synonyms | T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3 |
| Location | Cell membrane |
| Accession | P01730 |
| Clone Number | S-3691 |
| Antibody Type | Rat mAb |
| Isotype | Mouse IgG2b,k |
| Application | ELISA, FCM, in vitro blocking of CD4+ T cell activation, in vitro CD4 blockade |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD4 is a glycoprotein found on the surface of certain immune cells, such as helper T cells, monocytes, macrophages, and dendritic cells. It is a monomeric type I transmembrane molecule composed of four immunoglobulin-like domains (D1 to D4) and encoded by a single gene. As a co-receptor for the T-cell receptor (TCR), CD4 plays a crucial role in the immune response by binding to the MHC class II molecules on antigen-presenting cells, which helps T cells recognize and respond to foreign antigens. The interaction between CD4 and MHC class II molecules also activates downstream signaling pathways, leading to the activation of transcription factors and promoting T cell activation. Additionally, CD4 is significant in HIV infection, as the virus binds to CD4 to enter host cells.
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