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Description
Human REG1A Protein, His TagProduct Specification Species Human Synonyms Lithostathine 1 alpha, Islet cells regeneration factor (ICRF), Islet of Langerhans regenerating protein (REG), Pancreatic stone protein (PSP), Pancreatic thread protein (PTP), Regenerating islet derived protein 1 alpha (REG 1 alpha), Regenerating protein I alpha, PSPS, PSPS1, REG Accession P05451 Amino Acid Sequence Protein sequence (P05451, Gln23 Asn166, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Lithostathine-1-alpha, Islet cells regeneration factor (ICRF), Islet of Langerhans regenerating protein (REG), Pancreatic stone protein (PSP), Pancreatic thread protein (PTP), Regenerating islet-derived protein 1-alpha (REG-1-alpha), Regenerating protein I alpha, PSPS, PSPS1, REG |
| Accession | P05451 |
| Amino Acid Sequence | Protein sequence (P05451, Gln23-Asn166, with C-His Tag) QEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 18 kDa Observed MW: 18 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Lithostathine-1-alpha, also known as Regenerating islet-derived protein 1 alpha (REG1A), is a secreted protein encoded by the REG1A gene. It is primarily produced by the pancreas and plays a role in promoting cell proliferation and regeneration. Its name originates from its initial identification as a protein that inhibits calcium carbonate crystal formation, potentially preventing pancreatic stone formation. However, its primary significance lies in its function as a acute-phase reactant and its strong association with inflammatory and malignant conditions. REG1A is markedly overexpressed in diseases such as chronic pancreatitis and pancreatic ductal adenocarcinoma, making it a promising biomarker for early detection and monitoring of these conditions.
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