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Description
CD45 Recombinant Rabbit mAb (Alexa Fluor® 488 Conjugate) (S-R035)Product Specification Host Rabbit Antigen CD45 Synonyms Leukocyte common antigen (L CA) Location Cell membrane Accession P08575 Clone Number S R035 Antibody Type Recombinant mAb Isotype IgG Application ICC, IF Reactivity Hu Purification Protein A Concentration 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 0. 1% BSA, 0. 01% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as
Product Specification
| Host | Rabbit |
| Antigen | CD45 |
| Synonyms | Leukocyte common antigen (L-CA) |
| Location | Cell membrane |
| Accession | P08575 |
| Clone Number | S-R035 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ICC, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 0.1% BSA, 0.01% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| ICC | 1:100-1:200 | |
| IF | 1:100-1:200 |
Background
CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.
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