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Description
Mitofusin 2 Recombinant Rabbit mAb (S-1783-49)Product Specification Host Rabbit Antigen Mitofusin 2 Synonyms Mitofusin 2; Transmembrane GTPase MFN2; CPRP1; KIAA0214; MFN2 Immunogen Recombinant Protein Location Mitochondrion Accession O95140 Clone Number S 1783 49 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, HEK 293, HepG2, Jurkat, Raji, SK OV 3, NIH 3T3, mouse brain , mouse kidney, rat brain Purification Protein A Concentration
Product Specification
| Host | Rabbit |
| Antigen | Mitofusin 2 |
| Synonyms | Mitofusin-2; Transmembrane GTPase MFN2; CPRP1; KIAA0214; MFN2 |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion |
| Accession | O95140 |
| Clone Number | S-1783-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HEK-293, HepG2, Jurkat, Raji, SK-OV-3, NIH/3T3, mouse brain , mouse kidney, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
Mitofusin 2 (MFN2) is a dynamin-like GTPase protein anchored to the outer mitochondrial membrane, playing a crucial role in mitochondrial fusion, fission, and tethering to the endoplasmic reticulum (ER). It helps maintain mitochondrial morphology and function, and regulates intracellular calcium homeostasis and lipid metabolism. MFN2 is also involved in mitophagy by interacting with key proteins like PINK1 and Parkin, which mediate the selective elimination of damaged mitochondria. Mutations in the MFN2 gene are associated with Charcot–Marie–Tooth disease type 2A, a neurological disorder characterized by axonal degeneration and muscle atrophy. Additionally, MFN2 has been implicated in various cellular processes, including the regulation of the NLRP3 inflammasome and the maintenance of cell homeostasis. Its dual localization and diverse functions make it a critical regulator in both mitochondrial dynamics and interorganellar communication.
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