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Description
B7-H2/ICOSLG Recombinant Rabbit mAb (S-3306-12)Product Specification Host Rabbit Antigen CD275 Synonyms ICOS ligand; B7 homolog 2 (B7 H2); B7 like protein Gl50; B7 related protein 1 (B7RP 1); B7H2; B7RP1; ICOSL; KIAA0653; ICOSLG Immunogen Synthetic Peptide Location Cell membrane Accession O75144 Clone Number S 3306 12 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample Raji, Daudi, HL 60, MCF7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | CD275 |
| Synonyms | ICOS ligand; B7 homolog 2 (B7-H2); B7-like protein Gl50; B7-related protein 1 (B7RP-1); B7H2; B7RP1; ICOSL; KIAA0653; ICOSLG |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | O75144 |
| Clone Number | S-3306-12 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | Raji, Daudi, HL-60, MCF7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
CD275, also called ICOS ligand (ICOSL) or B7-H2, is a 40–60 kDa glycosylated type-I transmembrane protein encoded by the ICOSLG gene on chromosome 21 and classified within the B7 and immunoglobulin superfamilies; it is expressed on B cells, dendritic cells, macrophages, monocytes, endothelial cells and various non-hematopoietic tissues, can be rapidly up-regulated by IFN-γ, TNF-α or LPS, and serves as the indispensable ligand for the inducible costimulator ICOS on activated T cells, thereby delivering a critical positive co-stimulatory signal that drives T-cell activation, proliferation, Th2 cytokine secretion and the generation of follicular helper T cells and germinal centers while simultaneously promoting B-cell differentiation into plasma cells and antibody production during secondary immune responses, and plays additional roles in reactivating effector/memory T cells on inflamed endothelium to control tissue entry and in skewing maternal immunity toward a protective Th2 phenotype during pregnancy; its dysregulation contributes to infection, hypersensitivity, autoimmune diseases, transplantation immunity and tumor immunity, and alternative splicing yields multiple isoforms with distinct tissue distributions and functions.
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Exchange/Return Notes
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