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Description
Alexa Fluor 647-Labeled GUCY2C Fc Chimera Protein, HumanProduct Specification Species Human Synonyms GUC2C,STAR,STA receptor,hSTAR,GC C,DIAR6 Accession P25092 Amino Acid Sequence Ser24 Gln430 with Human IgG1 Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 95 120kDa Conjugation Alexa Fluor 647 Tag Human IgG1 Fc Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months from date of receipt, lyophilized powder stored at 20 to 80. 3 months, 20 to 80 under sterile
Product Specification
| Species | Human |
| Synonyms | GUC2C,STAR,STA receptor,hSTAR,GC-C,DIAR6 |
| Accession | P25092 |
| Amino Acid Sequence | Ser24-Gln430 with Human IgG1 Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 95-120kDa |
| Conjugation | Alexa Fluor® 647 |
| Tag | Human IgG1 Fc |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. Michael S. Magee,Crystal L. Kraft,Tara S. Abraham,Trevor R. Baybutt,Glen P. Marszalowicz,Peng Li: GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity. OncoImmunology, Volume 5, 2016 - Issue 10. |
Background
Guanylyl Cyclase C (GUCY2C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (GC) family expressed by intestinal epithelial cells from the duodenum to rectum. Mature human GUCY2C consists of an extracellular domain (ECD) with a ligand binding domain, a transmembrane segment and a cytoplasmic region possessing a kinase and GC catalytic domain. Endogenous ligands of GUCY2C include guanylin and uroguanylin. GUCY2C in epithelial cells plays an important role in cell dynamics and homeostatic balance of proliferation, metabolism, and differentiation that organizes the guanylyl cyclase C hormone axis. GUCY2C is also expressed in the brain and is implicated in attention deficiency and hyperactive behavior. The activation of cyclic guanosine monophosphate (cGMP), a second intracellular messenger, can stimulate the production of cyclic guanosine monophosphate (CGMP), which plays a role in regulating homeostasis, maintaining intestinal barrier function, and exerting anti-inflammatory activity.
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