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Description
Her4 His Tag Protein, HumanProduct Specification Species Human Synonyms Her4, ERBB4, 4ICD, MGC138404, p180erbB4 Accession Q15303 Amino Acid Sequence Gln26 Pro651, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | Her4, ERBB4, 4ICD, MGC138404, p180erbB4 |
| Accession | Q15303 |
| Amino Acid Sequence | Gln26-Pro651, with C-terminal 10*His QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 87-101kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Segers V F M. et al. (2020) The role of ErbB4 in cancer. Cell Oncol. 43: 335-352. 2、Xu J. et al. (2018) ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. Oncol Rep 39: 2892-2898. |
Background
HER4, also known as ErbB4, is a member of epidermal growth factor receptor (EGFR) or ErbB family. The HER4 gene is localized on chromosome 2q33.3–34. HER4 is necessary for normal development of body systems including heart, nervous system, and mammary gland. HER4 is commonly expressed in many human tissues, both adult and fetal. EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4 are members of this receptor tyrosine kinase family. HER4 is the only member of this family of receptors with growth inhibiting properties. HER4 can activate related genes in the nucleus when combined with epidermal growth factor (EGF), promoting cell division and proliferation. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. Her4 promotes glycolysis, glutaminolysis, mitochondrial biogenesis & OXPHOS through c-Myc-dependent signaling axis in cancer. The Her4-mediated metabolic reprogramming may in part cooperate to promote tumorigenesis in certain cancers.
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4.6 ★★★★★
Based on 20 reviews
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Product Reviews
★★★★★ 5
good product
Size: 16 AWG-100 ft
good product
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 21, 2025
★★★★★ 5
Good product at a great price
Size: 16 AWG-100 ft
Used to wire my door speakers and it worked amazing
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 21, 2026
★★★★★ 5
Smaller than the original, but works well.
When I received it, it was so small that I thought it was a toy, or maybe for some 4cyl engine. It is significantly smaller than the original one. When I looked closer, the mount holes did line up, so I tried it. I did have to get shorter mount bolts.
To my surprise, it works great! I don't know what the longevity will be, but it made it through a busy august!
Considering the price and how small it is, I might just buy a second one to keep on board. Just in case.
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Reviewed in the United States on September 14, 2025
★★★★★ 1
Warning!!!
I was so impressed after install!! Fired right up faster that it ever has in the past, had the boat out about 8 times and CACK!!! They say they will stand behind the product and replace it, but do I risk another day ruined on the river?
Btw, I have a Volvo penta 5.0 21.5' Larson I/O
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Reviewed in the United States on September 28, 2025
★★★★★ 5
Perfect fit and functioning. Excellent support
The starter fit perfectly, in my Mercruiser 4.3 from 2004, although it was awkward to replace on my engine due to space constraints. I had a few questions for the supplier and quickly received very descriptive answers. Now the starter works perfect in my boat. In all a very good choice which I really can recommend others.
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Reviewed in the United States on June 27, 2024
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