SKU: 52066979317

p300 Recombinant Rabbit mAb (S-2612-122)

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Description

p300 Recombinant Rabbit mAb (S-2612-122)Product Specification Host Rabbit Antigen p300 Synonyms Histone acetyltransferase p300; p300 HAT; E1A associated protein p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Protein 2 hydroxyisobutyryltransferase p300; Protein lactyltransferas p300; Protein propionyltransferase p300; EP300 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q09472 Clone Number S 2612 122 Antibody Type Recombinant mAb Isotype IgG

Product Specification


Host Rabbit
Antigen p300
Synonyms Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Protein 2-hydroxyisobutyryltransferase p300; Protein lactyltransferas p300; Protein propionyltransferase p300; EP300
Immunogen Recombinant Protein
Location Cytoplasm, Nucleus
Accession Q09472
Clone Number S-2612-122
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms
Positive Sample 293T, Jurkat, C2C12
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms
IHC-P 1:200 Hu
ICC 1:500 Hu

Background

p300 is a 2,414-residue human transcriptional coactivator that contains multiple conserved domains—bromodomain, CH1–CH3, HAT, KIX, and ZZ-type zinc finger—that enable it to serve as a histone acetyltransferase and a scaffold bridging sequence-specific DNA-binding factors with chromatin-remodeling machinery; by acetylating histones H3 and H4 as well as non-histone substrates such as p53 and NF-κB, it opens local chromatin structure and potentiates transcription, while its own activity is tightly regulated through phosphorylation, auto-acetylation, and competitive binding with viral oncoproteins like E1A or cellular partners like CBP; because it integrates proliferative, differentiation, and DNA-damage signals, p300 is indispensable during embryogenesis and is frequently altered—mutated, deleted, or translocated—in cancers, making it both a tumor suppressor and, in certain contexts, an oncogenic driver, and its HAT activity is pharmacologically targeted by small-molecule inhibitors under investigation for cancer therapy.

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SKU: 52066979317

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4.0 ★★★★★
Based on 18 reviews
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A
Verified Purchase
Amazon Customer
Chelsea, US
★★★★★ 4
Nice little travel solution for jewelry
Size: Medium (6.8"W*4.4"D*2.2"H), Color: Pink
Cute travel box for my jewelry. The necklace hangers aren’t all that snug, causing my necklaces to fall and tangle some. But otherwise, works as expected.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 19, 2026
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Brenda
Grantham, US
★★★★★ 5
would buy again
Size: Medium (6.8"W*4.4"D*2.2"H), Color: Beige
Love this jewelry case. perfect size for travel and at a good price
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Reviewed in the United States on May 21, 2026
M
Verified Purchase
Michelle Lough
Lake Worth, US
★★★★★ 5
It’s just as described. I love it. Very pretty and lots of space.
Size: Medium (6.8"W*4.4"D*2.2"H), Color: Beige
The quality of it was great. It’s very pretty and easy to travel with. Love the removable eaaring holder. Gives enough room for everything
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Reviewed in the United States on April 27, 2026
T
Verified Purchase
thyroyalreader
Whiting, US
★★★★★ 5
My fave ever
I bought this to travel for a summer camp and still use it, two years later! It is now my everyday jewelry container. The gold clasp has held up well and closes well. Very easy to use and structurally sound! I love the color and overall vibe of it too- very straight forward. I use the top portion for long earrings, so know if you do that, it can be finnicky, if you have fun or funky shaped earrings- so just know they may get caught but it's such an easy fix. I would say it is about the size of half of an American Girl doll. Maybe around the size of half a goose.
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Reviewed in the United States on May 8, 2026
K
Verified Purchase
kasxoxo
Boise, US
★★★★★ 5
Love this! Sturdy and elegant
I have a small selection of jewelry pieces I wear but I needed something that would keep them all together in one place. This jewelry box is fantastic! And It fits two pairs of sunglasses on the bottom compartment. I like that there’s a little tab to help pull up the top part. It was actually a bit bigger than expected which is a good thing. And still small enough for traveling. The necklace tabs are sturdy and hold them in place. I’m very satisfied with my purchase.
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Reviewed in the United States on March 1, 2025

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