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Description
PE-Cy7 Armenian hamster Anti-Human/mouse/rat CD278 Antibody (S-R578)Product Specification Host Armenian hamster Antigen CD278 Synonyms Inducible T cell costimulator; Activation inducible lymphocyte immunomediatory molecule; AILIM; ICOS Location Cell membrane Accession Q9Y6W8 Clone Number S R578 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu, Ms, Rt Purification Protein G Concentration 0. 2 mg ml Conjugation PE Cy7 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Armenian hamster |
| Antigen | CD278 |
| Synonyms | Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; AILIM; ICOS |
| Location | Cell membrane |
| Accession | Q9Y6W8 |
| Clone Number | S-R578 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD278, also known as ICOS (Inducible T-cell Costimulator), is a type I transmembrane glycoprotein that belongs to the CD28 family of costimulatory immunoreceptors. It is expressed on the surface of activated T cells, including cytotoxic T cells, regulatory T cells (Tregs), and other types of T cells. Its ligand, ICOSL (B7-H2 or CD275), is found on antigen-presenting cells (APCs) such as dendritic cells and macrophages, as well as on B cells. ICOS functions as a homodimer and plays a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. The interaction between ICOS and ICOSL enhances T-cell activation, proliferation, and differentiation, and is essential for the development of follicular helper T cells (Tfh) and efficient B-cell antibody responses. ICOS has also been implicated in various disorders, including immunodeficiency and autoimmune diseases. In cancer immunotherapy, ICOS expression has been identified as a potential predictive biomarker for responses to checkpoint inhibitor treatments.
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