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Description
MYG1 Recombinant Rabbit mAb (S-2248-25)Product Specification Host Rabbit Antigen MYG1 Synonyms MYG1 exonuclease; C12orf10 Immunogen Synthetic Peptide Location Nucleus, Mitochondrion Accession Q9HB07 Clone Number S 2248 25 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample SW480, LoVo, SW620, HCT 116 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | MYG1 |
| Synonyms | MYG1 exonuclease; C12orf10 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Mitochondrion |
| Accession | Q9HB07 |
| Clone Number | S-2248-25 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SW480, LoVo, SW620, HCT 116 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
MYG1 protein, also known as Melanocyte Proliferating Gene 1, is a dual-localized 3′-5′ RNA exonuclease found in both the nucleus and mitochondria. It plays a crucial role in RNA processing, specifically in the maturation of ribosomal and messenger RNA in mitochondria, which is essential for mitochondrial function and cellular respiration. MYG1 is involved in coordinating nuclear and mitochondrial translation programs, acting as a key mediator of nucleo-mitochondrial communication. In addition to its role in normal cellular function, MYG1 has been implicated in various pathological conditions. For instance, it is upregulated in colorectal cancer, where it promotes glycolysis and tumor progression through mechanisms involving the AMPK/mTOR signaling pathway. MYG1 is also associated with vitiligo, a skin disorder, and may be involved in antiviral responses.
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