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Description
FcRL1/CD307a His Tag Protein, HumanProduct Specification Species Human Synonyms FcR like protein 1, FcRL1, Fc receptor homolog 1 (FcRH1), CD307a Accession Q96LA6 Amino Acid Sequence Ala17 Asn303, with C terminal His Tag Expression System HEK293 Molecular Weight 37 49kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | FcR-like protein 1, FcRL1, Fc receptor homolog 1 (FcRH1), CD307a |
| Accession | Q96LA6 |
| Amino Acid Sequence | Ala17-Asn303, with C-terminal His Tag |
| Expression System | HEK293 |
| Molecular Weight | 37-49kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Davis, R.S. et al. (2007) Annu. Rev. Immunol. 25:525. |
Background
Fc receptor-like (FCRL) belongs to the Fc receptor-like (FcRL) family. The FCRL genes are located on chromosome 1q21-23 and encode 2 intracellular proteins (FCRL-A and B) and 6 transmembrane receptors with 3-9 immunoglobulin (Ig-like domains-in extracellular region (FcRL1-6). In addition, the FcRL gene family contained six members with FcRL1, FcRL2, FcRL3, FcRL4, FcRL5 and FcRL6. Among the FcRL receptors, FcRL1 has 2 ITAM-like components in the cytoplasmic tail and residual glutamic acids with negative charges its transmembrane region. FcRL1–5 was significantly expressed by B cells. FcRL6 was expressed by T cells and NK cells. To date, the FcRL gene expression has been extensively assessed in human malignancies involving mantle cell lymphoma and multiple myeloma. The structural features and expression pattern of FcRL1 in B-lineage cells suggest that it may act as an activation receptor in human B cell or plays a significant role in the pathogenesis of B-cell-related disorders. Nowadays, increasing researches have been provided many evidences which demonstrated that FcRL gene polymorphisms, especially FcRL3, were associated with various autoimmune diseases including AS and RA.
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