SKU: 56672274244

Carbonic Anhydrase IX/CA9 His Tag Protein, Mouse

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Description

Carbonic Anhydrase IX/CA9 His Tag Protein, MouseProduct Specification Species Mouse Antigen Carbonic Anhydrase IX CA9 Synonyms EC: 4. 2. 1. 1Renal cell carcinoma associated antigen G250P54 58NCarbonic Anhydrase 9RCC Associated Protein G250Carbonate Dehydratase IXCarbonic DehydrataseCA IXCAIXPMW1MNEC 4. 2. 1. 1G250Membrane antigen MNRCC associated antigen G250 Accession Q8VHB5 Amino Acid Sequence Gln32 Asp390, with C terminal 8*His

Product Specification


Species Mouse
Antigen Carbonic Anhydrase IX/CA9
Synonyms EC:4.2.1.1，Renal cell carcinoma-associated antigen G250，P54/58N，Carbonic Anhydrase 9，RCC-Associated Protein G250，Carbonate Dehydratase IX，Carbonic Dehydratase，CA-IX，CAIX，PMW1，MN，EC 4.2.1.1，G250，Membrane antigen MN，RCC-associated antigen G250
Accession Q8VHB5
Amino Acid Sequence

Gln32-Asp390, with C-terminal 8*His

QPQGLSGMQGEPSLGDSSSGEDELGVDVLPSEEDAPEEADPPDGEDPPEVNSEDRMEESLGLEDLSTPEAPEHSQGSHGDEKGGGHSHWSYGGTLLWPQVSPACAGRFQSPVDIRLERTAFCRTLQPLELLGYELQPLPELSLSNNGHTVQLTLPPGLKMALGPGQEYRALQLHLHWGTSDHPGSEHTVNGHRFPAEIHVVHLSTAFSELHEALGRPGGLAVLAAFLQESPEENSAYEQLLSHLEEISEEGSKIEIPGLDVSALLPSDLSRYYRYEGSLTTPPCSQGVIWTVFNETVKLSAKQLHTLSVSLWGPRDSRLQLNFRATQPLNGRTIEASFPAAEDSSPEPVHVNSCFTAGDGGGSHHHHHHHH
Expression System HEK293
Molecular Weight 43-55kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

·12 months from date of receipt, -20 to -70 °C as supplied. 

·1 month, 2 to 8 °C under sterile conditions after reconstitution.  

·Please avoid repeated freeze-thaw cycles.
Reference

1.Supuran CT. Carbonic anhydrases: noveltherapeutic applications for inhibitors and activators. Nat Rev Drug Discov2008;7:168–81.

2.McDonald PC, Swayampakula M, Dedhar S..Coordinated regulation of metabolic transporters and migration/invasion bycarbonic anhydrase IX. Metabolites 2018;8:E20.

Background

The CAIX works as a dimeric molecule composed of two monomeric proteins liked with a disulfide bond between cysteine residues of the two CAIX monomers, while the structure of CAXII is stabilized by 19 hydrogen-bonded interactions in the dimer interface. Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton.CAIX functions with bicarbonate transporters (including electroneutral bicarbonate transporter NBCn1 (SLC4A7)) to bring in HCO3- produced in a CAIX-mediated hydration reaction of CO2, and amino acid transporters (including the large neutral amino acid transporter 1 (LAT1) and CD98 heavy chain (CD98hc)) to transport in essential amino acids and glutamine (via interaction with glutamine transporter SLC1A5 and sodium-coupled neutral amino acid transporter 2 (SNAT2) facilitating the uptake of aminoacid by SLC1A5), which cancer cells employ as an alternative metabolic energy source and biosynthetic precursor. CAIX also creates unique interactions with collagen- and laminin-binding integrins at the leading edge of migrating cells.

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SKU: 56672274244

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4.7 ★★★★★
Based on 19 reviews
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S
Verified Purchase
Stephanie S.
Lexington, US
★★★★★ 2
Gave it a Try
I have always used the Chuck It ball and ball launcher. I thought I would try this since the price was better. There is definitely a reason it is priced lower. The handle on this one twists on and constantly comes undone when you throw, and it does not launch nearly as well. I would not order this product again.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 26, 2026
E
Verified Purchase
Elijah
Battle Creek, US
★★★★★ 4
A few usability issues
My dog is obsessed with playing fetch. It’s part of our daily routine. Pros - I like that this comes with two launchers so we can keep one at home and one in the car. - Build feels solid Cons - The cup is slightly too small for regular sized tennis balls. I buy the large Costco box of Penn tennis balls every couple of years for my dog. If you fully seat the ball in the cup/launching end, it’s extremely difficult to throw and puts some strain on your wrist. — the workaround is to only partially insert the ball when picking it up. - Like others have stated, the launcher does come unscrewed occasionally after a few throws. It’s kind of annoying so I’ll likely try some thread lock, but ideally that wouldn’t be necessary.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 15, 2026
P
Verified Purchase
Peter J Anderson
Phoenix, US
★★★★★ 5
Fun!!!
I can’t say enough good things about this tennis ball launcher! Roxy absolutely loves it. Every time I pick it up, her tail goes crazy with excitement. It’s so easy on my arm, and I love that it gives her a great way to burn off energy. The launcher is sturdy, well-made, and works like a charm. If you have a high-energy pup like Roxy, this is a must-have!
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Reviewed in the United States on May 21, 2026
D
Verified Purchase
D. Rodriguez
Draper, US
★★★★★ 3
Fun along with frustration….
The product is good. The only problem is that the dark blue handle screws onto the lighter blue stick, and every 5-10 throws it comes unscrewed, and you have to screw them back tight. Maybe if they put a little bump in the handle and an indent on the handle so they could click into place it would work fine.
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Reviewed in the United States on May 27, 2026
L
Verified Purchase
Literally doesn’t work
Grantham, US
★★★★★ 5
Great Value Toy
Color: Crinkle Duck (Blue), Size: Large, Color: Crinkle Duck (Blue), Size: Large
This toy has been one of my dog’s absolute favorites. He gets excited every time he sees it and will carry it around the house, toss it in the air, and keep himself entertained for a long time. The shape and texture seem perfect for him, and it quickly became one of his go-to toys over everything else in his basket. What I really like is that it holds up reasonably well for the price. It’s definitely not indestructible, and after a lot of play, it will sometimes start to rip—usually around the feet first since that’s where my dog tends to grab and chew the most. But honestly, considering how affordable it is, I don’t mind replacing it when needed. It’s inexpensive enough that rebuying feels worth it because he genuinely loves it that much. I’d rather keep buying a toy he is obsessed with than spend more on something that just sits untouched. It’s fun, cute, and keeps him happy, which is what matters most. Overall, I’d definitely recommend it for dogs who love plush toys and playful chewing.
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Reviewed in the United States on April 28, 2026

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