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Description
Invivo Anti-Mouse IL-4 Recombinant mAbProduct Specification Host Rat Antigen IL 4 Synonyms Interleukin 4; B cell IgG differentiation factor; B cell growth factor 1; B cell stimulatory factor 1 (BSF 1); IGG1 induction factor; Lymphocyte stimulatory factor 1; Il 4; Il4 Location Secreted Accession P07750 Clone Number S 3840 Antibody Type Rat mAb Isotype Rat IgG1,k Application ELISA, WB, in vivo IL 4 neutralization, in vitro IL 4 neutralization, in vivo IL 4 receptor stimulation (as a complex
Product Specification
| Host | Rat |
| Antigen | IL-4 |
| Synonyms | Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1 (BSF-1); IGG1 induction factor; Lymphocyte stimulatory factor 1; Il-4; Il4 |
| Location | Secreted |
| Accession | P07750 |
| Clone Number | S-3840 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG1,k |
| Application | ELISA, WB, in vivo IL-4 neutralization, in vitro IL-4 neutralization, in vivo IL-4 receptor stimulation (as a complex with IL-4) |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000-1:50000 | Ms |
Background
Interleukin-4 (IL-4) is a 15–20 kDa, glycosylated, four-α-helical cytokine secreted primarily by Th2-polarized CD4⁺ T cells, mast cells, basophils and eosinophils that signals through a heterodimeric receptor complex composed of the IL-4Rα chain paired with either the common γ chain (type I, hemopoietic cells) or the IL-13Rα1 chain (type II, non-hemopoietic cells) to activate JAK1/3–STAT6 and IRS1/2 pathways, thereby driving commitment of naïve CD4⁺ T cells to the Th2 lineage, promoting immunoglobulin class-switching to IgG1 and IgE in B cells, inducing alternative activation (M2) of macrophages that orchestrate tissue repair and fibrosis, stimulating mucus production and smooth muscle remodeling in airway epithelium, and acting as a central mediator of allergic inflammation, asthma pathogenesis and resistance to helminth parasites, while also exerting context-dependent anti-inflammatory effects that limit Th1/Th17 responses and autoimmune damage.
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Exchange/Return Notes
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