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Description
c-Raf Recombinant Rabbit mAb (S-2718-61)Product Specification Host Rabbit Antigen c Raf Synonyms RAF proto oncogene serine threonine protein kinase; Proto oncogene c RAF (cRaf); Raf 1; RAF; RAF1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Mitochondrion, Cell membrane Accession P04049 Clone Number S 2718 61 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, A549, C2C12, NIH 3T3, PC 12, COS 7 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | c-Raf |
| Synonyms | RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF (cRaf); Raf-1; RAF; RAF1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Mitochondrion, Cell membrane |
| Accession | P04049 |
| Clone Number | S-2718-61 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, A549, C2C12, NIH/3T3, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
| ICC | 1:100 | Hu |
Background
c-Raf (also called Raf-1) is a 648-amino-acid serine/threonine kinase that serves as the pivotal upstream cytoplasmic MAP3K in the classical Ras→Raf→MEK→ERK/MAPK cascade: upon growth-factor- or oncogenic Ras-GTP-mediated recruitment to the plasma membrane, it homo- or hetero-dimerizes, becomes phosphorylated on multiple activating residues (Ser338, Tyr341, Thr491, Ser494) while relieving N-terminal autoinhibition, and then processively phosphorylates MEK1/2 to trigger downstream proliferative, anti-apoptotic, and differentiative transcriptional programs; its activity is tightly controlled via feedback and scaffold proteins, and gain-of-function mutations, overexpression, or dysregulated upstream signaling of c-Raf are implicated in numerous cancers, making it a key therapeutic target.
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