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Description
Human Desmoglein 3, His tagProduct Specification Species Human Synonyms 130 kDa pemphigus vulgaris antigen (PVA), Cadherin family member 6, DSG3, CDHF6 Accession P32926 Amino Acid Sequence Protein sequence(Q29432, Arg54 Val380, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | 130 kDa pemphigus vulgaris antigen (PVA), Cadherin family member 6, DSG3, CDHF6 |
| Accession | P32926 |
| Amino Acid Sequence | Protein sequence(Q29432, Arg54-Val380, with C-10*His) RGSNLTTHPLRNIKDLVYMGNITIGTPPQEFQVVFDTASSDLWVPSDFCTSPACSTHVRFRHLQSSTFRLTNKTFRITYGSGRMKGVVVHDTVRIGNLVSTDQPFGLSIEEYGFEGRIYDGVLGLNYPNISFSGAIPIFDKLKNQRAISEPVFAFYLSKDEREGSVVMFGGVDHRYYEGELNWVPLIQAGDWSVHMDRISIERKIIACSDGCKALVDTGTSDIVGPRRLVNNIHRLIGAIPRGSEHYVPCSEVNTLPSIVFTINGINYPVPGRAYILKDDRGRCYTTFQENRVSSSTETWYLGDVFLRLYFSVFDRGNDRIGLARAVGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:17.6kDa Actual:20-30kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene. In the skin epidermis Desmoglein-3 is expressed in the basal lower layers of the epidermis, and dominates in terms of expression on mucosal surfaces compared to Desmoglein-1. Desmoglein-3, along with Desmoglein-1, has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. The mucosal dominant form of pemphigus vulgaris only involves antibodies against Desmoglein-3 and causes mucosal erosions, but no skin lesions. Desmoglein-3 serves as a prognostic marker of Esophageal Squamous Cell Carcinoma (ESCC), and may even be involved in the progression of ESCC.
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4.6 ★★★★★
Based on 8 reviews
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Product Reviews
★★★★★ 5
Precision meets style - a game changer for culinary enthusiasts
Just received Typhur InstaProbe my latest kitchen gadget, an ultra-premium meat thermometer, and let me tell you - this is not your average thermometer. It cost about a lot more than the standard meat thermometer, but every single penny is worth it for the level of accuracy and convenience it brings to the table.
The speed and precision of this thermometer are unrivaled. It takes readings in a split second, completely eliminating the need to wait around while your hand hovers over the heat, or loss of precious heat from your oven. The accuracy is pinpoint - to the decimal. No more guesswork, no more undercooked or overcooked meats. Every meal I've made since getting this thermometer has been cooked to absolute perfection, making me feel like a gourmet chef in my own kitchen.
The aesthetic and tactile quality of this thermometer is another feature that sets it apart. It's sleek, modern, and feels premium in your hand. It's not just a tool, but an accessory to my kitchen that is both functional and pleasing to the eye.
Despite the price tag, this thermometer is worth considering for those who value precision, speed, and style in their cooking. The level of control it gives you over your cooking is unparalleled, and it's incredibly easy to use. It's a must-have for serious home cooks, barbecue enthusiasts, or anyone who values precision in their cooking. It's a worthwhile investment that will transform your cooking experience and elevate your meals to new heights. And as the old saying goes - you get what you pay for. With this premium meat thermometer, you're getting the very best.
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Reviewed in the United States on June 12, 2023
★★★★★ 5
Great quality
I’m just a hobbyist, but this is the best fast read temperature probe I’ve ever used. Performance is top notch. The build quality is excellent, especially the display screen. You will be able to read it in any light situation. The temperature reading stabilized very quickly, ambidextrous response is also very fast. Obviously to turn the unit on you will need to swing the probe out. It has good magnet strength, but, in cases where you have a true stainless steel grill or prep table, just lay it down, in out position, it will awaken within a second when picked up. Close the probe, it will stay off till next use. The box it is shipped in makes for great storage, just make sure to keep the outer sleeve of the box. The probe itself is very sharp (but, be careful) unlike some others, which makes it very easy to push in to the most delicate, to the very tough cuts of meat at any temperature. It uses 2AAA batteries which are are very versatile, unlike the 2032 lithium batteries that others use. I understand that alot of people use these products in cold temperatures in which alkaline batteries will not work well, but you can get AAA lithium batteries for cold weather conditions. Just make sure you remove the alkaline batteries when the probe will not be used for long periods of time due to corrosion. All in all, a great product, it’s built with quality materials and should last a very long time. Quality over quantity. Also, they offer a 10 year warranty once you register your probe. They actually reached out to me after I purchased it and left a phone number. I called them and actually spoke to a real representative of the company. You may pay more for this temp probe than 100’s of others that are less expensive, but, I feel that Typhur stands behind their products.
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Reviewed in the United States on June 26, 2024
★★★★★ 5
Fast, Accurate, and Fancy - The Ultimate Thermometer Experience!
I recently purchased this thermometer, and I am beyond impressed with its performance, design, and user experience. The key features that set it apart are its speed, accuracy, and the inclusion of a fancy OLED display.
The very first thing I noticed was how fast this thermometer delivers accurate readings. Within mere seconds, I had a precise temperature reading, eliminating the need for any guesswork. I've tested it on multiple occasions, and it consistently provided reliable results.
One aspect that truly stands out is the fancy OLED display. Not only is it aesthetically pleasing, but it also enhances the user experience by providing clear and easy-to-read measurements. The display is bright and visible even in low light conditions, making it incredibly convenient for those late-night fever checks.
In summary, this thermometer is a fantastic investment for anyone in need of a fast, accurate, and visually appealing device. Its remarkable speed, precision, and the added touch of a fancy OLED display make it a must-have in any household.
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Reviewed in the United States on May 2, 2023
★★★★★ 5
Best Thermometer by far.
Size: 6.5"
What a fantastic product. You would not be unsatisfied buying this Thermometer. It’s quick and accurate. I’ve been using it for about a year now and completely recommend it for pros and amateurs.
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Reviewed in the United States on May 13, 2026
★★★★★ 5
Very handy and capable thermometer for measuring internal temps of cooking meat
Size: 6.5"
A very-fast (and I think accurate) thermometer for tracking internal temps of cooking meat to insure doneness and that your meat is cooked to a safe temp. The sharp point of the probe slides into dense meats with ease. I have found this a very helpful accessory for frying and slow-cooking meats. It's display is VERY easy to read, even outdoors in bright light, or indoors in dimmer light. Haven't had it long enough to comment on battery life, though in two months, and almost daily use, no sign yet of needing a recharge.
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Reviewed in the United States on March 24, 2026